A popular theoretical framework to compute the permeability coefficient of a molecule is provided by the classic Smoluchowski-Kramers treatment of the steady-state diffusive flux across a free-energy barrier. Within this framework, commonly termed "inhomogeneous solubility-diffusion" (ISD), the permeability, P, is expressed in closed form in terms of the potential of mean force and position-dependent diffusivity of the molecule of interest along the membrane normal. In principle, both quantities can be calculated from all-atom MD simulations. Although several methods exist for calculating the positiondependent diffusivity, each of these is at best an estimate. In addition, the ISD model does not account for memory effects along the chosen reaction coordinate. For these reasons, it is important to seek alternative theoretical formulations to determine the permeability coefficient that are able to account for the factors ignored by the ISD approximation. Using Green-Kubo linear response theory, we establish the familiar constitutive relation between the flux density across the membrane and the difference in the concentration of a permeant molecule, j = PΔC. On this basis, we derive a time-correlation function expression for the nonequilibrium flux across a membrane that is reminiscent of the transmission coefficient in the reactive flux formalism treatment of transition rates. An analysis based on the transition path theory framework is exploited to derive alternative expressions for the permeability coefficient. The different strategies are illustrated with stochastic simulations based on the generalized Langevin equation in addition to unbiased molecular dynamics simulations of water permeation of a lipid bilayer.