Self-reported data collected independently by the UK-based Control Group Cooperative between September 2021 and February 2022, inclusive, from a self-selected international COVID-19 “unvaccinated” population are discussed. Data come from a cohort of 18,497 participants who provided questionnaire responses monthly. The largest numbers are from Europe, North America, and Australasia. Data were skewed towards the 40-69y age range and included 60% female respondents. Reasons for avoiding COVID-19 “vaccines” were: a preference for natural medicine, distrust of pharma, distrust of government information, poor/limited trial data, and fear of long-term adverse reactions. During the survey period, the greatest incidence of COVID-19 disease was reported in the 50-69y range, peaking at 12.3%, in January 2022. Persons at 70y and above were least affected (1.3%), with 10.7% and 3.8% in the 20 to 49y band, and in the 1 to 19y group, respectively. Most rated their symptoms as “mild” (14.4%), with 2% reporting “severe” disease. Fatigue, cough, muscle/body aches, and fever were the four most common. Just 0.4% of the cohort reported hospitalization (as in- or out-patients). Nearly two-thirds reported taking vitamin D, C, zinc, quercetin, or a combination, for prevention, with 71% using vitamin D, C, and zinc for treatment. Nearly 45% reported “moderate” to “severe” mental health issues (depression) during the survey period. Menstrual abnormalities were reported by 36% of women in the 20-49y age band. Reported job losses were greatest in Australia and New Zealand at 29%, followed by 13% in North America. Between 20% and 50% reported being personal targets of hate because of their vaccination status. Between 57% and 61% of respondents in Southern Europe and Western Europe, Australia/New Zealand and South America, reported being targets of governmental victimization. The cohort may not be representative of wider populations given its reliance on self-care. The findings suggest that opting out of the world’s largest medical experiment, relying on natural immunity, self-care with supplements, and/or ivermectin or hydroxychloroquine, appeared to contribute to low incidences of severe disease, hospitalization, or death. The results imply the urgent need for prospective studies of “unvaccinated”, “partially vaccinated”, and “fully vaccinated” persons investigating long-term outcomes, behaviors, choices, and discriminatory responses by the state, institutions, or employers based on “vaccination” status. Public dialogue about the touted “safety and effectiveness” of vaccines, contrasted with strategies to enhance immune resilience, all in the context of authoritarianism versus autonomy, self-care, personal responsibility, and freedom of choice is needed.