How lifestyle factors and their associated pathogenetic mechanisms impact psoriasis

Madden, Seonad K.; Flanagan, Katie L.; Jones, Graeme

doi:10.1016/j.clnu.2019.05.006

Cited by 37 publications

(53 citation statements)

References 145 publications

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“…Only a few studies are exploring the influence of lifestyle factors on psoriasis pathogenesis, and no guidelines regarding dietary recommendations. Evidence is accumulating that by lifestyle modifications and incorporating food components, such as EFAs it is possible to produce standalone benefits among sufferers and improve psoriasis severity [119].…”

Section: Psoriasis and Pufasmentioning

confidence: 99%

Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases

Balić

Vlašić

Žužul

et al. 2020

IJMS

225

116

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Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.

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Section: Psoriasis and Pufasmentioning

confidence: 99%

Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases

Balić

Vlašić

Žužul

et al. 2020

IJMS

225

116

View full text Add to dashboard Cite

show abstract

“…The skin comprises the dermis and the epidermis, which has a multilayer structure comprising basal, spinous, and granular cell layers. During differentiation, keratinocytes can gradually move from the basal layer to differentiate into the upper layers of the epidermis and eventually desquamate (Madden et al, 2020b). The abnormal function of neutral lipids, which makes it difficult to secrete into the extracellular space, results in a defective water/ vapor barrier and shedding of the SC.…”

Section: The Clinical Findings and Histopathological Features Of Psoriasismentioning

confidence: 99%

Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis

Xie

Huang

et al. 2021

Front. Pharmacol.

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Psoriasis, an incurable autoimmune skin disease, is one of the most common immune-mediated disorders. Presently, numerous clinical research studies are underway, and treatment options are available. However, these treatments focus on improving symptoms of the disease and fail to achieve a radical cure; they also have certain toxic side effects. In recent years, natural products have increasingly gained attention because of their high efficiency and low toxicity. Despite their obvious therapeutic effects, natural products’ biological activity was limited by their instability, poor solubility, and low bioavailability. Novel drug delivery systems, including liposomes, lipospheres, nanostructured lipid carriers, niosomes, nanoemulsions, nanospheres, microneedles, ethosomes, nanocrystals, and foams could potentially overcome the limitations of poor water solubility and permeability in traditional drug delivery systems. Thus, to achieve a therapeutic effect, the drug can reach the epidermis and dermis in psoriatic lesions to interact with the immune cells and cytokines.

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“…Dietas anti-inflamatórias, focadas na redução da ingestão de lipídios, devem ser priorizadas pela assistência nutricional. O uso de probióticos e prebióticos ainda é discutido, pois há associação entre baixas ingestão de ômega-3 e disbiose com agravo da psoríase, o que, em tese, poderia ser equilibrado por meio de reguladores da microbiota intestinal (ROUSSET L e HALIOUA B, 2018; ZENG J, et al, 2019; MADDEN SK, et al, 2019).…”

Section: Revisão Bibliográficaunclassified

“…As áreas mais afetadas são joelhos, cotovelos, couro cabeludo e região lombar, frequentemente acompanhada de prurido ou dor. Sua etiologia é desconhecida, porém acredita-se haver envolvimento genético, imunológico e ambiental (LAHOUSEN T, et al, 2016;MADDEN SK, et al,2019;YUKSEL EP, et al, 2019).…”

Section: Introductionunclassified

Estresse e psoríase: novas abordagens no tratamento

et al. 2020

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Este artigo tem como objetivo fazer uma revisão analisando a respeito da influência do estresse psicológico em pacientes com Psoríase. Essa é uma doença dermatológica crônica de etiologia desconhecida, não contagiosa e que afeta cerca de 2% da população mundial, atingindo homens e mulheres na mesma proporção. É uma enfermidade muito relacionada ao estresse psicológico e ao constrangimento causado pelas lesões na pele. O estresse estimula os eixos de liberação do hormônio corticotrófico (CRH), sendo esse hormônio o sinalizador do aumento da produção de cortisol nas células das glândulas adrenais. No entanto, os hormônios quando em desequilíbrio, atuam no sistema imunológico e a pele é um órgão sensível a essas variações. Sendo assim, configura-se um dos fatores chave tanto no estabelecimento, quanto na manutenção das lesões da psoríase. Portanto, o estresse psicológico é considerado um dos eixos principais do tratamento da Psoríase, pois intervenções que visam o alívio deste, em conjunto com as terapias convencionais, além de acelerar a remissão da doença, diminuem os níveis séricos de cortisol nesses pacientes.

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How lifestyle factors and their associated pathogenetic mechanisms impact psoriasis

Cited by 37 publications

References 145 publications

Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases

Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases

Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis

Estresse e psoríase: novas abordagens no tratamento

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