This article explores the intersection of structural and actor-oriented explanations of populism through a territorial perspective, focusing on populist Euroscepticism. It builds on findings from the ‘Local Mobilisation Against the EU. Territorial Dimensions of Populist Euroscepticism’ (EULOC) project, which examined local drivers and manifestations of populism and Euroscepticism across Europe. The article highlights the importance of analysing both the supply and demand sides of populist Euroscepticism, emphasising the role of geographic inequalities, local socio-economic trajectories and collective identities. By integrating national, regional and local case studies, the article aims to bridge the divide between structural and actor-oriented approaches, offering a more comprehensive understanding of populist Euroscepticism. This approach seeks to prevent reductionist arguments and contributes to broader discussions on political participation, representation and the dynamics of populist movements in Europe. The article underscores the need for nuanced, multi-layered research that considers the unique socio-political dynamics of different regions and the impact of local contexts on the development of Eurosceptic sentiments.