How Long can we Store Blood Samples: A Systematic Review and Meta-Analysis

Wu, Dongwen; Li, Yumeng; Wang, Fen

doi:10.1016/j.ebiom.2017.09.024

Cited by 52 publications

(34 citation statements)

References 24 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have stated diverse acceptable storage times for blood samples, ranging from 2 to 72 hours, depending on the degree of storage temperatures. In higher storage temperature, the acceptable storage time was shorter [9, 15–19] (Fig 3). In the present study, the mean storage time was less than 2 hours (maximum 350 min) and the average storage temperatures were somewhat higher than the average room temperature (20–25 degree Celsius) which ensured the accuracy of laboratory results according to the standard.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of laboratory tests collected at referring hospitals versus tertiary care hospitals for acute stroke patients

et al. 2019

View full text Add to dashboard Cite

Background The standard treatment of acute ischemic stroke patients is thrombolytic therapy within 60 minutes of a patient’s arrival in stroke center hospitals. Based on the policy of the Lampang Referral System Committee, blood samples of suspected stroke patients need to be collected before transfer to the stroke center (Lampang Hospital). It was still questionable as to whether these blood samples are valid for clinical use and the present study aimed to confirm or deny their validity. Methods A diagnostic study was conducted from June 2015 to May 2016. After exclusion, 340 patients were deemed eligible for analysis. Blood samples were collected just before normal saline infusion at referring hospitals and stored in blood collecting tube boxes set during transportation. At the stroke center, informed consents was requested, blood samples were re-collected to serve as a ‘gold standard’. Prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), platelet count, hemoglobin (Hb), hematocrit (Hct), blood urea nitrogen (BUN), and creatinine (Cr) were compared using paired t-tests. Binary regression was used to analyze for accuracy (%) to adjust for extraneous influences and was presented by modified Bland-Altman plots. Results The laboratory results of referring hospitals vs. the stroke center were: PT, 12.4±3.2 vs. 12.5±3.0 sec; INR: 1.0±0.3 vs. 1.0±0.3; and platelet count: 239.8±77.1 vs. 239.8±74.8 (x103/μL). The adjusted accuracy of the PT, INR, and platelet counts were 96.8%, 96.8%, and 95.3% respectively. Conclusion Laboratory tests from referring hospital were determined to be valid. Blood samples should thus be collected at referring hospitals in order to avoid unnecessary blood collection at the stroke center.

show abstract

Section: Discussionmentioning

confidence: 99%

Accuracy of laboratory tests collected at referring hospitals versus tertiary care hospitals for acute stroke patients

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The daily processes in a laboratory generate substantial amounts of data, mostly in electronic form, that must be catalogued and archived to ensure credibility and quality of test results. Laboratory documentation must be archived efficiently to save money and space, improve productivity, allow rapid information sharing, protect patient privacy and be environmentally sustainable ( 70 - 72 ).…”

Section: Procedures 7: Archiving Of Laboratory Documentationmentioning

confidence: 99%

Post-analytical laboratory work: national recommendations from the Working Group for Post-analytics on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine

Krleža

Honović²,

Tanasković³

et al. 2019

Biochem. med. (Online)

View full text Add to dashboard Cite

The post-analytical phase is the final phase of the total testing process and involves evaluation of laboratory test results; release of test results in a timely manner to appropriate individuals, particularly critical results; and modification, annotation or revocation of results as necessary to support clinical decision-making. Here we present a series of recommendations for post-analytical best practices, tailored to medical biochemistry laboratories in Croatia, which are intended to ensure alignment with national and international norms and guidelines. Implementation of the national recommendations is illustrated through several examples.

show abstract

“…Often the extraanalytical factors such as different transportation conditions, prolonged storage at high or low temperature, improper handling that may affect analysis process are not monitored. Previous studies showed that prolonged storage of whole blood samples lead to deterioration in stability of most analytes when subjected to different time-point measurements [4,[10][11][12][13][14][15][16][17]. Studies showed stability for a wide range of plasma analytes on blood samples kept at 21 0 C [7,17].…”

Section: Introductionmentioning

confidence: 99%

Large Academic Hospital Laboratory Investigates a Major Pre-Analytical Challenge in Africa and Developing Countries

Buthelezi¹,

Marule²,

Motlonye³

et al. 2019

PLM

View full text Add to dashboard Cite

Background: Delay in serum separation from red blood cells in samples collected from most primary healthcare facilities and transported to a laboratory for analysis is of great concern. Standard guidelines state that serum or plasma should be separated from cells within 2 hours of collection. The aim was to determine effects of delayed sample separation on measured biochemical analytes. The objective was to store blood samples in primary collection tubes at 20-25°C post venesection, then separate, and analyse samples of selected analytes. Methods: Multiple sample tubes of whole blood were collected from one of the authors volunteer, and subjected to time delays in centrifugation. The baseline serum was separated from red blood cells within 30 minutes of post venesection to allow adequate coagulation. Twenty analytes were studied using 2 analytical platforms. Percentage variation and standard error method were used to evaluate time-dependent variability in analytes. Total change limit was used to measure significant changes within-run variability for both platforms. Results: Most analytes were stable up to day 3 to 4 on both platforms. Serum CO 2 , CL, Ca, ALT and ALB were stable up to 8 days when they were measured on Cobas 8000®. BUN, TRIG, TB, CHOL, AST, ALT and ALB were stable up to 10 days on Dimension® CCS. K showed significant changes at 2h on both platforms at initial measurements. It was out-of-range at day 10 on Dimension® CCS. Serum creatinine levels showed substantial changes at day 2 on Dimension® analyzer and on Cobas 8000® at day 3. Conclusions: The study showed stability of wide range of serum analytes at 20-25°C for several days. The acceptable results can be achieved if samples are centrifuged the same day and analyzed later for most of biochemical analytes.

show abstract

How Long can we Store Blood Samples: A Systematic Review and Meta-Analysis

Cited by 52 publications

References 24 publications

Accuracy of laboratory tests collected at referring hospitals versus tertiary care hospitals for acute stroke patients

Accuracy of laboratory tests collected at referring hospitals versus tertiary care hospitals for acute stroke patients

Post-analytical laboratory work: national recommendations from the Working Group for Post-analytics on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine

Large Academic Hospital Laboratory Investigates a Major Pre-Analytical Challenge in Africa and Developing Countries

Contact Info

Product

Resources

About