How long do nosocomial pathogens persist on inanimate surfaces? A systematic review

Krämer, Axel; Schwebke, Ingeborg; Kampf, Günter

doi:10.1186/1471-2334-6-130

Cited by 2,101 publications

(1,782 citation statements)

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“…More effective antibacterial films are needed at present due to the increasing resistance of pathogenic bacteria to synthetic antibiotics when administered for long times [2]. Recently, Mills et al [3], Parkin et al [4][5][6][7], Foster et al [8], Dunlop et al [9] and Yates et al [10] have reported antibacterial films of Ag and Cu films on glass and thin polymer films by chemical vapor deposition (CVD) and in some cases sputtering techniques.…”

Section: Introductionmentioning

confidence: 99%

Coupling of narrow and wide band-gap semiconductors on uniform films active in bacterial disinfection under low intensity visible light: Implications of the interfacial charge transfer (IFCT)

Rtimi

Sanjinés

Pulgarín

et al. 2013

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Coupling of narrow and wide band-gap semiconductors on uniform films active in bacterial disinfection under low intensity visible light: Implications of the interfacial charge transfer (IFCT)

Rtimi

Sanjinés

Pulgarín

et al. 2013

Journal of Hazardous Materials

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“…The field of antibacterial Cu films/surfaces has gained much attention during the last decade since they decrease/eliminate hospital-acquired infections involving antibiotic-resistant bacteria surviving for long times (Foster et al 2010) (Dunlop et al 2010). The Cu films avoid chemicals to clean/disinfect hospital rooms leaving residues after use (Kramer et al 2006). Recently, Gabbay et al (2006), Borkow and Gabbay (2008) and also Gedanken (2004) have reported the application of Cu textiles composites as antimicrobial surfaces.…”

Section: Introductionmentioning

confidence: 99%

Inactivation of bacteria under visible light and in the dark by Cu films. Advantages of Cu-HIPIMS-sputtered films

Ehiasarian

Pulgarín

Kiwi

2012

Environ Sci Pollut Res

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Introduction The Cu polyester thin-sputtered layers on textile fabrics show an acceptable bacterial inactivation kinetics using sputtering methods. Materials and methods Direct current magnetron sputtering (DCMS) for 40 s of Cu on cotton inactivated Escherichia coli within 30 min under visible light and within 120 min in the dark. For a longer DCMS time of 180 s, the Cu content was 0.294% w/w, but the bacterial inactivation kinetics under light was observed within 30 min, as was the case for the 40-s sputtered sample. Results and discussion This observation suggests that Cu ionic species play a key role in the E. coli inactivation and these species were further identified by X-ray photoelectron spectroscopy (XPS). The 40-s sputtered samples present the highest amount of Cu sites held in exposed positions interacting on the cotton with E. coli. Cu DC magnetron sputtering leads to thin metallic semi-transparent gray-brown Cu coating composed by Cu nanoparticulate in the nanometer range as found by electron microscopy (EM). Cu cotton fabrics were also functionalized by bipolar asymmetric DCMSP. ConclusionSputtering by DCMS and DCMSP for longer times lead to darker and more compact Cu films as detected by diffuse reflectance spectroscopy and EM. Cu is deposited on the polyester in the form of Cu 2 O and CuO as quantified by XPS. The redox interfacial reactions during bacterial inactivation involve changes in the Cu oxidation states and in the oxidation intermediates and were followed by XPS. High-power impulse magnetron sputtering (HIPIMS)-sputtered films show a low rugosity indicating that the texture of the Cu nanoparticulate films were smooth. The values of R q and R a were similar before and after the E. coli inactivation providing evidence for the stability of the HIPIMSdeposited Cu films. The Cu loading percentage required in the Cu films sputtered by HIPIMS to inactivate E. coli was about three times lower compared to DCMS films. This indicates a substantial Cu metal savings within the preparation of antibacterial films.

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“…Survival on dry inanimate surfaces can be between 3 days and 4 months, depending on the strain, and contributes to the successful persistence of Acinetobacter infections in health care settings [5,6]. A. baumannii has been isolated from hospital equipment, bedding, furniture and staff [7].…”

Section: Introductionmentioning

confidence: 99%

Increasing Occurrence of Multidrug-Resistance in Acinetobacter baumannii Isolates From Four German University Hospitals, 2002–2006

et al. 2010

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Background: Acinetobacter baumannii can cause severe infections, mainly in critically ill inpatients. Treatment is complicated by multidrug-resistance (MDR). In Germany, to date, little is known on the extent of MDR in A. baumannii isolated from inpatients in German hospitals (OR 1.8,). The lowest in vitro antibiotic resistance was found in meropenem, imipenem and ampicillin/sulbactam, with 33, 37 and 39% for multidrugresistant and 0.4, 1 and 3% in non-multidrug-resistant A. baumannii

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How long do nosocomial pathogens persist on inanimate surfaces? A systematic review

Abstract: Background: Inanimate surfaces have often been described as the source for outbreaks of nosocomial infections. The aim of this review is to summarize data on the persistence of different nosocomial pathogens on inanimate surfaces.

Cited by 2,101 publications

References 110 publications

Coupling of narrow and wide band-gap semiconductors on uniform films active in bacterial disinfection under low intensity visible light: Implications of the interfacial charge transfer (IFCT)

Coupling of narrow and wide band-gap semiconductors on uniform films active in bacterial disinfection under low intensity visible light: Implications of the interfacial charge transfer (IFCT)

Inactivation of bacteria under visible light and in the dark by Cu films. Advantages of Cu-HIPIMS-sputtered films

Increasing Occurrence of Multidrug-Resistance in Acinetobacter baumannii Isolates From Four German University Hospitals, 2002–2006

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