How many skin barriers haveth we: Percutaneous egression of ions?

Chiang, Chavy; Maibach, Howard I.

doi:10.1111/srt.13119

Cited by 4 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Minimizing thermal sweating, hence, is crucial for quantifying TEWL under basal conditions. A low TEWL is a characteristic feature of a balanced, healthy skin protective state 6 . TEWL measurements can be used to assess the inside‐out barrier.…”

Section: Discussionmentioning

confidence: 99%

“…Since its introduction, the TEWL has been applied in different fields of dermatological practice and research, as skin barrier physiology parameter in healthy and diseased skin, proof of concept for the cosmetic industry, monitoring therapeutic efficacy, occupational aspects of skin disease, and finally as a predictor for asthma and atopic dermatitis development 6–10 …”

Section: Introductionmentioning

confidence: 99%

“…5 Since its introduction, the TEWL has been applied in different fields of dermatological practice and research, as skin barrier physiology parameter in healthy and diseased skin, proof of concept for the cosmetic industry, monitoring therapeutic efficacy, occupational aspects of skin disease, and finally as a predictor for asthma and atopic dermatitis development. [6][7][8][9][10] The measurement uncertainty of classic probes has physical limits because diffusion is a dynamic process. 11 It is based on the random Brownian motion of air and water molecules.…”

mentioning

confidence: 99%

See 2 more Smart Citations

In vivo transepidermal water loss: Validation of a new multi‐sensor open chamber water evaporation system Tewameter TM Hex

Fluhr

Wiora²,

Nikolaeva

et al. 2023

Skin Research and Technology

View full text Add to dashboard Cite

Background Instrumentation technology for transepidermal water loss measurements has not been substantially modified since its introduction by Nilsson in 1977. Recent progress in sensor development allowed a new sensor arrangement using a matrix of 30 sensors. Raw measurement values are processed with spatial statistical analysis. We aimed to compare the new, multi‐sensor probe (Tewameter TM Hex) with the established Tewameter TM 300 probe and to gain reference data for the new parameters of transepidermal energy loss and water vapor concentration on skin. Material and methods Baseline measurements and repeated measurements on the volar forearm and assessment on eight different anatomical locations were performed on 24 healthy volunteers (both gender) with the TM Hex and the TM 300. Results A significant correlation (p < 0.001; R‐coefficient = 0.9) between TM Hex and the TM 300 with a low coefficient of variance (CV) 11% for TM Hex and 19% for TM 300, could be assessed. The CV ranged between 7% (right inner upper arm) and 14% (palms). Average transepidermal heat loss ranged from 12 W/m2 on the lower leg to 38.8 W/m2 on the palm. Conclusion The correlation between TM Hex and TM 300 along with the robustness of the measurements with the TM Hex shows that the new probe for assessment of epidermal barrier function is comparable to the TM 300. In most conditions, TM Hex provides more accurate measurements than TM 300. New parameters open the field to studying skin's water and energy balance.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

In vivo transepidermal water loss: Validation of a new multi‐sensor open chamber water evaporation system Tewameter TM Hex

Fluhr

Wiora²,

Nikolaeva

et al. 2023

Skin Research and Technology

View full text Add to dashboard Cite

show abstract

“…It has been also reported that polymorphism in the thymic stromal lymphopoietin (TSLP) gene and its receptor, as well as dysregulation of genes involved in the metabolism of epidermal lipids, are associated with an increased risk of AD, its resistance, and food allergy. Other mutations of the skin barrier, including the SPINK5 gene and сorneodesmosin mutations, are also associated with AD and the development of food allergy [ 7 , 11 ]. Newborns with increased transepidermal water loss (TEWL) in the first week of life had an increased risk of developing AD at 12 months of age [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The hen and the egg question in atopic dermatitis: allergy or eczema comes first

Allenova

Darlenski

2023

asthma res and pract

View full text Add to dashboard Cite

Atopic dermatitis (AD) as a chronic inflammatory systemic condition is far more than skin deep. Co-morbidities such as asthma and allergic rhinitis as well as the psychological impact influence seriously the quality of life of the patients. Recent studies have shown that only 10% of atopic patients undergo full manifestation of the atopic march, while 40% demonstrate concomitant food allergy. Exposure to food allergens in the environment causes sensitization and food allergy through the disruption of the skin barrier, as in AD. Food allergy and AD are closely related. While not all AD patients have a food allergy, 20–40% of children with moderate to severe AD will have an IgE-mediated food allergy. It is known that they may coexist but it is unclear if food allergy worsens the course of AD. Experimental, clinical, and epidemiological studies have provided evidence of the primary role of an epidermal barrier defect in the development of sensitization to environmental allergens and that this process occurs in the damaged skin barrier rather than the gastrointestinal or respiratory tract. There is strong evidence for a connection between early AD onset and the development of other allergic diseases later in life.

show abstract