2023
DOI: 10.1242/dmm.050393
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How metals fuel fungal virulence, yet promote anti-fungal immunity

Alanoud Alselami,
Rebecca A. Drummond

Abstract: Invasive fungal infections represent a significant global health problem, and present several clinical challenges, including limited treatment options, increasing rates of antifungal drug resistance and compounding comorbidities in affected patients. Metals, such as copper, iron and zinc, are critical for various biological and cellular processes across phyla. In mammals, these metals are important determinants of immune responses, but pathogenic microbes, including fungi, also require access to these metals t… Show more

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Cited by 7 publications
(2 citation statements)
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“…Copper’s therapeutic spectrum comprises by antipathogenic (antibacterial [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ], antiviral [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ], and antifungal [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ] activity), anticancer [ 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ], hemostatic [ 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ], angiogenic [ 91 , 92 , 93 , 94 , …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Copper’s therapeutic spectrum comprises by antipathogenic (antibacterial [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ], antiviral [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ], and antifungal [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ] activity), anticancer [ 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ], hemostatic [ 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ], angiogenic [ 91 , 92 , 93 , 94 , …”
Section: Introductionmentioning
confidence: 99%
“…Copper's therapeutic spectrum comprises by antipathogenic (antibacterial [41][42][43][44][45][46][47][48][49][50], antiviral [51][52][53][54][55][56][57][58][59][60], and antifungal [61][62][63][64][65][66][67][68][69][70] activity), anticancer [71][72][73][74][75][76][77][78][79][80], hemostatic [81][82][83][84][85][86][87][88][89][90], angiogenic [91]…”
Section: Introductionmentioning
confidence: 99%