How Might Circadian Rhythms Control Mood? Let Me Count the Ways...

McClung, Colleen A.

doi:10.1016/j.biopsych.2013.02.019

Cited by 408 publications

(328 citation statements)

References 102 publications

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“…Related to the biochemical findings, this is the first study that we are aware of to report such a significant increase in BDNF with treatment, as well as an increase in irisin. The interplay between sleep quality and quantity, mood and perceived energy level, and cognitive function has been previously described [30]- [32]. Additional work focused on the mechanisms of effect of the botanical agent to improve measures of sleep quality, mood, and cognitive health may be warranted.…”

Section: Resultsmentioning

confidence: 93%

Impact of a Dietary Supplement Containing Rosemary and Daylily on Biochemical Markers of Cognitive Health, Sleep Quality and Related Variables in Men and Women

MacDonnchadh¹,

Moran²,

Timmcke³

et al. 2016

Health

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Background: We investigated the influence of a botanical agent to improve sleep quality and associated measures in men and women with self-reported difficulty sleeping. Methods: 32 individuals were randomly assigned in double blind manner to ingest a botanical agent (CLOCK®, containing Rosemary [Rosmarinus officinalis] and Daylily [Hemerocallis fulva]) or a placebo over a 6-week intervention. During weeks 1 and 2, subjects ingested one serving of the assigned condition, followed by a two-week washout. During weeks 5 and 6, subjects ingested two servings of the condition. The Leeds Sleep Evaluation Questionnaire was used as an outcome measure, as were subjective measures of sleep quality, energy level, and mood. Blood samples collected pre-and post-intervention were assayed for acetylcholine (ACH), brainderived neurotrophic factor (BDNF), irisin, and melatonin. Results: No differences were noted between conditions in measures of sleep (p > 0.05). While no differences of statistical significance were noted in subjective feelings, during weeks 5 and 6 as compared to baseline, subjects assigned to the supplement noted an 8% increase in attentiveness, an 11% increase in alertness, a 12% increase in focus, a 14% increase in feeling energetic, a 12% increase in enthusiasm, a 23% increase in feeling well rested, an 11% decrease in feeling sluggish, and a 16% decrease in feeling depressed, without the same improvement observed for subjects in the placebo group. All biochemical measures were increased from pre-to post-treatment with two servings of the supplement; the largest percent increase noted for BDNF (27%) and the largest effect 1308 mood, with a significant impact on the biochemical marker, BDNF. Future studies using a larger sample size and perhaps a cross-over design may help to further clarify the impact of this dietary supplement on aspects of sleep quality, mood, and other related variables.

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Section: Resultsmentioning

confidence: 93%

Impact of a Dietary Supplement Containing Rosemary and Daylily on Biochemical Markers of Cognitive Health, Sleep Quality and Related Variables in Men and Women

MacDonnchadh¹,

Moran²,

Timmcke³

et al. 2016

Health

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“…This relationship has been observed at the molecular, physiological, and behavioral levels. 4 However, little is known about the 24-hour rhythm of other behavioral and physiological functions, such as mood, cognitive abilities, appetite, and social interaction.…”

Section: Introductionmentioning

confidence: 99%

The Mood Rhythm Instrument: development and preliminary report

Souza

Carissimi

Costa

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To describe the initial steps in the development and validation of a new self-reported instrument designed to assess daily rhythms of mood symptoms, namely, the Mood Rhythm Instrument. Methods: A multidisciplinary group of experts took part in systematic meetings to plan the construction of the instrument. Clarity of items, their relevance to evaluation of mood states, and the consistency of findings in relation to the available evidence on the biological basis of mood disorders were investigated. The internal consistency of the questionnaire was evaluated through Cronbach's alpha. Results: All of the items proposed in a first version were well rated in terms of clarity. The items more frequently rated as ''rhythmic'' were related to the somatic symptoms of mood. Their peaks in 24 hours were more frequent in the morning. The items associated with affective symptoms of mood were rated as less rhythmic, and their peak in 24 hours occurred more frequently in the afternoon and evening. Males and females behaved more similarly with respect to somatic than behavioral-affective items. The second version of the Mood Rhythm Instrument had a Cronbach's alpha of 0.73. Conclusion:The proposed Mood Rhythm Instrument may be able to detect individual rhythms of cognitive and behavioral measures associated with mood states. Validation in larger samples and against objective measures of rhythms, such as actigraphy, is warranted.

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“…Multiple studies have reported an association between bipolar disorder and stressful early life events such as gestational hunger (Brown et al, 2000), gestational influenza (Machon et al, 1997;Parboosing et al, 2013), childhood abuse (Daglas et al, 2014;Etain et al, 2008;Gilman et al, 2014) and early parental loss (Morotensen et al, 2003). Early life events that may induce circadian dysfunction are of particular interest since bipolar disorder involves the disruption of many biological rhythms affecting the 24 hour sleepwake cycle, energy and alertness (Giglio et al, 2009;McClung, 2013;Murray and Harvey, 2010;Wirz-Justice, 2006). The most recognized symptoms of circadian disruption are ongoing sleep disturbances that increase prior to and during episodes (Murray and Harvey, 2010;Ng 2014).…”

Section: Introductionmentioning

confidence: 99%