How might the consideration of cell polarity affect the daily therapeutic practise? A review study.

Abstract

Background: In addition to biochemical gradients and transcriptional networks, the behaviour of cells is controlled by endogenous bioelectrical signals resulting from the action of ion channels and pumps. Both biochemical and transcription network modifications can have their impacts through bioelectric modifications, and bioelectric modifications by producing polarity can act as precursor patterns for future genetic evolutions and biochemical modifications. In further details, the proliferation, differentiation, cell shape, and death of stem, progenitor, and somatic cells are governed by instructive messages mediated by variations in resting potential. Cells are regulated not only by their own Vmem (membrane resting potential) but also by the Vmem of their neighbours, establishing networks through electrical synapses known as gap junctions. Changes in the spatial and temporal distribution of Vmem in nonneuronal somatic tissues produce cell polarity which govern pattern development and act as signals that establish the polarity of the body's anatomical axis, and initiate limb regeneration. This article discusses how variations in cell polarity can induce clinical problems and how examining cell polarity might aid in symptom management. Methods: Using Ovid-MEDLINE, Cochrane central, PubMed, Scopus, Web of Science (WOS), and Embase, a comprehensive qualitative literature review was conducted from February 1, 2018, through February 1, 2023. This evaluation includes all types and designs of studies involving the phrases bioelectric, cell polarity, electroceuticals, human, people, diseases, illnesses, and foot and ankle problems, which were connected using the conjunctions "and" and "or." Results: From a total of 1281 publications identified, 27 were chosen. One of this research investigated bioelectric wound healing. 25 studies addressed bioelectric nerve cell growth, whereas one evaluated bioelectricity-induced cellular differentiation in the treatment of arteriopathies. Conclusion: After analysing the data, the author recommends that cell polarity be addressed for the treatment and prevention of most, if not all, foot and ankle problems. This strategy will assist in addressing most of the predisposing factors and healing impediments for a disease, hence enhance healing process and reducing the likelihood of recurrence or parallel conditions. Due to the limits of bioelectricity measurement and the involvement of mechanical and chemical gradients, more studies are required to confirm these results.