How Much Heparin Intraperitoneally Is Necessary in CAPD?

Gries, E.; Paar, D.; Graben, N

doi:10.1159/000185067

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…The assumption of a linear relationship between log 10 [R] and log 10 [W] was checked with the Pearson correlation coefficient. With these regression lines a predicted D/P ratio was determined for every procoagulant and fibrinolytic factor in each patient.…”

Section: Discussionmentioning

confidence: 99%

“…Let X k be the mean log 10 both Goedde et al [1] and Gries et al [37] found in their patients on stable peritoneal dialysis.…”

Section: Discussionmentioning

confidence: 99%

“…Addition of 500 U heparin/l of dialysate is shown to be sufficient to inhibit intraperitoneal fibrin formation without a systemic anticoagulant effect [9,10]. Recently Nadig et al [8] concluded from their studies that heparinization is effective in patients with low DD levels in the dialysate at the time of peritonitis.…”

Section: Discussionmentioning

confidence: 99%

“…For each individual k, let: W i be the molecular weight of non-procoagulant and fibrinolytic factor i; W f be the molecular weight of procoagulant and fibrinolytic factor f; R i be the measured D/P ratio of non-procoagulant and fibrinolytic factor i; R f be the measured D/P ratio of procoagulant and fibrinolytic factor f. Of N individuals, for each individual k, the regression line of log 10 f is assumed to be the same for all procoagulant and fibrinolytic factors and equal to σ 2 , the variance in the de-…”

Section: Appendixmentioning

confidence: 99%

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Intraperitoneal hypercoagulation and hypofibrinolysis is present in childhood peritonitis

Boer

Levi

Reddingius

et al. 1999

Pediatric Nephrology

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An increased rate of obstruction of peritoneal dialysis catheters is observed during peritonitis. Hypercoagulation and hypofibrinolysis may explain this increased occurrence. We studied plasminogen activator inhibitor type 1 antigen (PAI-1), tissue-type plasminogen activator antigen (t-PA), D-dimer (DD), plasmin-alpha2-antiplasmin complexes (PAP), and thrombin-antithrombin III complexes (TAT) in 7 children with peritonitis (group A) and 12 children during stable peritoneal dialysis (group B). Albumin, beta2-microglobulin, IgG, and alpha2-macroglobulin were measured for baseline transperitoneal protein transport. After a dwell of 6 h with 1.36% Dianeal, dialysate and serum samples were collected. Dialysate to plasma ratios of all proteins were calculated. During peritonitis (group A) TAT was higher: 34.7 versus 22.0 (P=0.01). PAI-1 was increased in group A: 76.5 versus 22.9 (P=0.004). PAP was decreased during peritonitis (group A): 24.9 versus 39.3 (P=0.01). In group A, DD were decreased. 10.8 versus 26.7 (P=0.002). t-PA was similar in both groups (23.7 in group A vs. 27.7 in group B; P=0.26). In both groups TAT, PAI-1, t-PA, PAP, and DD were significantly higher than in baseline transperitoneal transport, suggesting intraperitoneal production. Hypercoagulability and hypofibrinolysis were present during peritonitis compared with the control situation.

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Section: Discussionmentioning

confidence: 99%

“…Let X k be the mean log 10 both Goedde et al [1] and Gries et al [37] found in their patients on stable peritoneal dialysis.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Appendixmentioning

confidence: 99%

See 2 more Smart Citations

Intraperitoneal hypercoagulation and hypofibrinolysis is present in childhood peritonitis

Boer

Levi

Reddingius

et al. 1999

Pediatric Nephrology

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“…Mori et al [15] reported that almost all of the AT III antigen found in the dialysate maintained its heparin cofactor activity in CAPD patients. Recently, Gries et al [16] reported that the application of 500 U/l of heparin was enough to inhibit the intraperitoneal fibrin forma tion and in 2 patients fibrin formation was suppressed even during peritonitis. Addition of AT III increased the inhibition of intraperitoneal fibrin formation by heparin.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Heparin and/or Antithrombin III on Intraperitoneal Fibrin Formation in Continuous Ambulatory Peritoneal Dialysis

Tabata

Shimada²,

Emoto³

et al. 1990

Nephron

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The intraperitoneal fibrin formation and its inhibition by intraperitoneal heparin and/or antithrombin III (AT III) were examined in 8 patients on continuous ambulatory peritoneal dialysis (CAPD). With 1,000 and 2,000 U/L of heparin added to inflow dialysate, the concentration of fibrinopeptide A (FPA) in plasma decreased from 39.43 ± 5.30 (mean ± SEM) to 8.00 ± 2.20 and to 0.74 ± 0.12 ng/ml, respectively. The FPA concentration in outflow dialysate decreased from 34.20 ± 5.75 to 12.94 ± 2.10 ng/ml (1,000 U/l of heparin) and to 4.54 ± 0.79 ng/mg (2,000 U/l of heparin). The AT III concentration was 0.47 ± 0.07 mg/dl in dialysate and that in plasma was 24.20 ± 2.76 mg/dl. With 100 U/bag of AT III added to inflow dialysate, the AT III concentration increased from 0.47 ± 0.07 to 3.36 ± 0.17 mg/dl in outflow dialysate but did not increase in plasma. The inhibition of fibrin formation of intraperitoneal heparin was increased by addition of AT III without a systemic inhibitory effect on fibrin formation. These data suggest that intraperitoneal administration of heparin without AT III would be sufficient for the purpose of preventing fibrin formation in CAPD patients without any trouble, and additional AT III might increase inhibitory effect of heparin.

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Anticoagulation and the kidney

Combe¹,

Aparicio²

1994

Anticoagulation

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How Much Heparin Intraperitoneally Is Necessary in CAPD?

Cited by 6 publications

References 2 publications

Intraperitoneal hypercoagulation and hypofibrinolysis is present in childhood peritonitis

Intraperitoneal hypercoagulation and hypofibrinolysis is present in childhood peritonitis

Inhibitory Effect of Heparin and/or Antithrombin III on Intraperitoneal Fibrin Formation in Continuous Ambulatory Peritoneal Dialysis

Anticoagulation and the kidney

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