How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults

Marcu, Loredana G.; Chau, Minh; Bezak, Eva

doi:10.1016/j.critrevonc.2021.103292

Cited by 25 publications

(13 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the brain cancer is considered to be the 10th leading cause of death in both women and men. In 2019, around 17 760 adults (7850 women and 9910 men) were estimated to have died from the primary cancerous brain (Marcu, et al, 2021). Every year, hundreds of thousands of patients worldwide undergo radiotherapy for primary brain tumors and for brain metastases originating from extracranial tumors (Reichl, et al, 2022).…”

Section: Significance Of the Studymentioning

confidence: 99%

needs of patients receiving brain radiotherapy at Fayoum oncology center

Ali¹,

Alwani²,

Shaban³

et al. 2022

ijhs

View full text Add to dashboard Cite

Background: Brain radiotherapy is an indispensable mainstay treatment for the majority of brain tumors. It has an important role in the treatment of brain tumors either with curative intent or for palliation. Although radiotherapy is well tolerated by most patients, some experience radiation-induced side effects. Aim of the study: To assess the needs of patients receiving brain radiotherapy at fayoum oncology center. Design: Descriptive exploratory research design was used to conduct this study. Setting: The study was conducted in the radiotherapy unit at Fayoum Oncology Center at fayoum governorate. Subjects: A purposive sample of 60 adult patients from both gender receiving brain radiotherapy. Tools: A structured interviewing questionnaire included socio-demographic data, medical history, surgical history and patients' health needs assessment questionnaire. Results: the highest unfulfilled health needs of patients treated with brain radiotherapy were discomfort, activities of daily living, anxiety and depression. There is statistically significant correlation between physical health needs, psychological and social health needs. Additionally, there is statistically significant correlation between physical discomfort and anxiety and between physical discomfort and depression Conclusion: The study concluded that the patients suffered from unfulfilled health needs physical, social and psychological.

show abstract

Section: Significance Of the Studymentioning

confidence: 99%

needs of patients receiving brain radiotherapy at Fayoum oncology center

Ali¹,

Alwani²,

Shaban³

et al. 2022

ijhs

View full text Add to dashboard Cite

show abstract

“…The recent work of Marcu et al. ( 21 ) offers a systematic review on epidemiological studies covering cumulative doses and cancer risks in children and young adults’ examinations.…”

Section: Introductionmentioning

confidence: 99%

Determining Out-of-Field Doses and Second Cancer Risk From Proton Therapy in Young Patients—An Overview

Romero-Expósito

Toma-Daşu²,

Daşu³

2022

Front. Oncol.

View full text Add to dashboard Cite

Proton therapy has the potential to provide survival and tumor control outcomes comparable and frequently superior to photon therapy. This has led to a significant concern in the medical physics community on the risk for the induction of second cancers in all patients and especially in younger patients, as they are considered more radiosensitive than adults and have an even longer expected lifetime after treatment. Thus, our purpose is to present an overview of the research carried out on the evaluation of out-of-field doses linked to second cancer induction and the prediction of this risk. Most investigations consisted of Monte Carlo simulations in passive beam facilities for clinical scenarios. These works established that equivalent doses in organs could be up to 200 mSv or 900 mSv for a brain or a craniospinal treatment, respectively. The major contribution to this dose comes from the secondary neutrons produced in the beam line elements. Few works focused on scanned-beam facilities, but available data show that, for these facilities, equivalent doses could be between 2 and 50 times lower. Patient age is a relevant factor in the dose level, especially for younger patients (by means of the size of the body) and, in addition, in the predicted risk by models (due to the age dependence of the radiosensitivity). For risks, the sex of the patient also plays an important role, as female patients show higher sensitivity to radiation. Thus, predicted risks of craniospinal irradiation can range from 8% for a 15-year-old male patient to 58% for a 2-year-old female patient, using a risk model from a radiological protection field. These values must be taken with caution due to uncertainties in risk models, and then dosimetric evaluation of stray radiation becomes mandatory in order to complement epidemiological studies and be able to model appropriate dose–response functions for this dose range. In this sense, analytical models represent a useful tool and some models have been implemented to be used for young patients. Research carried out so far confirmed that proton beam therapy reduces the out-of-field doses and second cancer risk. However, further investigations may be required in scanned-beam delivery systems.

show abstract

“…The number and complexity of fluoroscopically guided procedures continue to grow, as does the concern over elevated levels of radiation dose. The rising number of high dose imaging investigations increases the stochastic risk of oncogenesis with lengthy procedures also resulting in patient skin erythema [ 1 ]. Radiation exposure in the catheterization laboratory (cath lab) is notably higher than that of other fluoroscopic departments [ 2 ], and increased rates of subcapsular cataracts have been reported in cath lab staff [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of dose reducing software on patient and staff temple dose during fluoroscopically guided pacemaker insertion, closure devices implantation and coronary angiography procedures

et al. 2022

View full text Add to dashboard Cite

The aim of this study is to investigate the effectiveness of dose reducing software (ClarityIQ) on patient and staff dose during fluoroscopically guided cardiac procedures. Dose measurements were collected in a room without dose reducing software (n = 157) and compared with similar procedures performed in two rooms with the software (n = 1141). Procedures included diagnostic coronary angiography, percutaneous coronary intervention, deployment of cardiac closure devices (for occlusion of atrial septal defect, patent foramen ovale, and atrial appendage) and insertion of permanent pacemakers. The dose reducing software was found to be effective in reducing patient and staff dose by approximately 50%. This study has added to the limited literature reporting on the capability of dose reducing software to decrease radiation exposure during the implantation of cardiac closure devices, as well as demonstrating a reduction in dose to the cardiologist and nursing staff. Administrators should ensure timely upgrades to angiographic equipment to safeguard patients and staff against the potentially adverse effects of radiation exposure. Regardless of the use of dose reducing software, the mean occupational dose during closure devices was in descending order scout > scrub > cardiologist. Scrub nurse dose was found to be higher than the cardiologist during closure devices (0.98/0.26 μSv) and diagnostic coronary angiograms (1.51/0.82 μSv). Nursing staff should be aware that their levels of radiation dose during some cardiac procedures may come close to or even exceed that of the cardiologist.

show abstract

How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults

Cited by 25 publications

References 62 publications

needs of patients receiving brain radiotherapy at Fayoum oncology center

needs of patients receiving brain radiotherapy at Fayoum oncology center

Determining Out-of-Field Doses and Second Cancer Risk From Proton Therapy in Young Patients—An Overview

Impact of dose reducing software on patient and staff temple dose during fluoroscopically guided pacemaker insertion, closure devices implantation and coronary angiography procedures

Contact Info

Product

Resources

About