The end-to-end spectral efficiency and bit error rate (BER) of an amplify-and-forward (AF) radio relay chain employing orbital angular momentum (OAM) multiplexing is presented. The inherent divergence of a beam carrying OAM is overcome by means of a lens. Modelled and measured inter-modal crosstalk levels are incorporated into the analysis. The results show that an end-to-end spectral efficiency of up to 8 bits s−1 Hz−1 is achievable using four OAM modes to multiplex four parallel data streams over 20 hops, provided that the detrimental effects of inter-modal crosstalk are mitigated. The spectral efficiency is expected to scale further by using more OAM modes. The BER profile along the relay chain is analysed for each of the four OAM modes.