How people wake up is associated with previous night’s sleep together with physical activity and food intake

Vallat, Raphaël; Berry, Sarah; Tsereteli, Neli; Capdevila, Joan; Khatib, Haya Al; Valdes, Ana M.; Delahanty, Linda M.; Drew, David A.; Chan, Andrew T.; Wolf, Jonathan; Franks, Paul W.; Spector, Tim D.; Walker, Matthew P.

doi:10.1038/s41467-022-34503-2

Cited by 9 publications

(9 citation statements)

References 66 publications

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“…This explanation fits previous findings that daytime sleepiness is not solely caused by short sleep (Horne, 2010) and that increased duration does not necessarily cause longer sleep latency and less sleepiness even within individuals (Roehrs et al, 1996). It also concurs with the results from a recent study showing very modest effects of variations in within-participant sleep duration on subjective alertness (Vallat et al, 2022). Recent meta-analyses of twin studies found 38% (Madrid-Valero et al, 2020) and 46% (Kocevska et al, 2021a) of the variability in self-reported sleep duration to be explained by genetics, with GWAS estimates typically being around 10% (Garfield, 2021).…”

Section: Individual Differences In Sleep Needsupporting

confidence: 92%

Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers

et al. 2023

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Many sleep less than recommended without experiencing daytime sleepiness. According to prevailing views, short sleep increases risk of lower brain health and cognitive function. Chronic mild sleep deprivation could cause undetected sleep debt, negatively affecting cognitive function and brain health. However, it is possible that some have less sleep need and are more resistant to negative effects of sleep loss. We investigated this using a cross-sectional and longitudinal sample of 47,029 participants of both sexes (20-89 years) from the Lifebrain consortium, Human Connectome project and UK Biobank, with measures of self-reported sleep, including 51,295 MRIs of the brain and cognitive tests. 740 participants who reported to sleep < 6 hours did not experience daytime sleepiness or sleep problems/disturbances interfering with falling or staying asleep. These short sleepers showed significantly larger regional brain volumes than both short sleepers with daytime sleepiness and sleep problems (n = 1742) and participants sleeping the recommended 7-8 hours (n = 3886). However, both groups of short sleepers showed slightly lower general cognitive function, 0.16 and 0.19 standard deviations, respectively. Analyses using acelerometer-estimated sleep duration confirmed the findings, and the associations remained after controlling for body mass index, depression symptoms, income and education. The results suggest that some people can cope with less sleep without obvious negative associations with brain morphometry, and that sleepiness and sleep problems may be more related to brain structural differences than duration. However, the slightly lower performance on tests of general cognitive abilities warrants closer examination in natural settings.Significance statementShort habitual sleep is prevalent, with unknown consequences for brain health and cognitive performance. Here we show that daytime sleepiness and sleep problems are more strongly related to regional brain volumes than sleep duration. However, participants sleeping ≤ 6 hours had slightly lower scores on tests of general cognitive function. This indicates that sleep need is individual, and that sleep duration per se is very weakly if at all related brain health, while daytime sleepiness and sleep problems may show somewhat stronger associations. The association between habitual short sleep and lower scores on tests of general cognitive abilities must be further scrutinized in natural settings.

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Section: Individual Differences In Sleep Needsupporting

confidence: 92%

Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers

et al. 2023

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“…This supports our hypothesis that sleep duration would show a significant linear association with navigation ability that would differ by gender. Accordingly, this finding aligns with previous findings of a gender difference in the effect of sleep duration on cognitive function in a large cohort (Jackowska & Cadar, 2020), but not with studies where no association has been found in both navigation and non-navigation-related domains (Ngyuen et al, 2013; Vallat et al, 2022; van Oostrom et al, 2018). Several factors may have accounted for these discrepancies, such as circadian rhythms and the time one spends awake during the day, which have been found to influence gender differences in cognitive function and which were not examined here (Santhi et al, 2016).…”

Section: Discussionsupporting

confidence: 91%

Shorter self-reported sleep duration in men is associated with worse virtual spatial navigation performance

Yavuz,

Lazar,

Gahnstrom

et al. 2023

Preprint

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Sleep has been shown to impact navigation ability. However, it remains unclear how different sleep-related variables may be independently associated with spatial navigation performance, and as to whether gender may play a role in these associations. We used a mobile video game app, Sea Hero Quest (SHQ), to measure wayfinding ability in US-based participants. Wayfinding performance on SHQ has been shown to correlate with real-world wayfinding. Participants were asked to report their sleep duration, quality, daytime sleepiness and nap frequency and duration (n = 737, 409 men, 328 women, mean age = 27.1 years, range = 18-59 years). A multivariate linear regression was used to identify which sleep variables were independently associated with wayfinding performance. For men, longer sleep durations were associated with better wayfinding performance. For women, no such association was found. While other sleep variables showed trends of association with wayfinding performance, none of these were significantly associated with wayfinding performance in our regression model. These findings from younger U.S.-based participants suggest that a longer sleep duration may be an important contributor to successful navigation ability in men.

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“…Such trait variability may partly be accounted for by genetic differences (Linkowski 1999;Landolt 2011;Dashti et al 2019). This explanation fits previous findings that daytime sleepiness is not solely caused by short sleep (Horne 2010), that increased duration does not necessarily cause longer sleep latency and less sleepiness even within individuals (Roehrs et al 1996), and the results from a recent study showing very modest effects of variations in within-participant sleep duration on subjective alertness (Vallat et al 2022). Recent meta-analyses of twin studies found 38% (Madrid-Valero et al 2020) and 46% (Kocevska, Barclay, et al 2021) of the variability in self-reported sleep duration to be explained by genetics, with GWAS estimates typically being around 10% (Garfield 2021).…”

Section: Individual Differences In Sleep Needsupporting

confidence: 90%

Is short sleep bad for the brain? Brain structure and cognitive function in short sleepers

Fjell

Sørensen

Wang

et al. 2022

Preprint

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Many sleep less than recommended without experiencing daytime tiredness. According to prevailing views, short sleep increases risk of lower brain health and cognitive function. Chronic mild sleep deprivation could cause undetected sleep debt, negatively affecting cognitive function and brain health. However, it is possible that some have less sleep needs and are more resistant to negative effects of sleep loss. We investigated this question using a combined cross-sectional and longitudinal sample of 47,029 participants (age 20-89 years) with measures of self-reported sleep, including 51,295 MRIs of the brain and cognitive tests. 701 participants who reported to sleep < 6 hours did not experience any daytime tiredness or sleep problems. These short sleepers showed on average larger regional brain volumes and only slightly lower general cognitive function compared to a group of 7-8 hours healthy sleepers (n = 3754). In contrast, short sleepers reporting excessive daytime tiredness and sleep problems (n = 1619) had smaller brain volumes and lower cognitive scores. Analyses using accelerometer-estimated sleep duration confirmed the findings, and the associations remained after controlling for body mass index, depression symptoms, income and education. The results suggest that some people can cope with less sleep without obvious negative consequences for brain health, in line with a view on sleep need as individualized. Tiredness and sleep problems seem to be more relevant for neurocognitive function than sleep duration per se.

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How people wake up is associated with previous night’s sleep together with physical activity and food intake

Cited by 9 publications

References 66 publications

Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers

Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers

Shorter self-reported sleep duration in men is associated with worse virtual spatial navigation performance

Is short sleep bad for the brain? Brain structure and cognitive function in short sleepers

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