How phototherapy affects the relation between serum bilirubin and plasma malondialdehyde in neonates

Öztüre, Hülya; Duman, Murat; Duman, Nuray; Özkan, Hasan

doi:10.1136/fn.82.2.f171a

Cited by 7 publications

(6 citation statements)

References 4 publications

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“…All the published studies are related to the oxidative effects of phototherapy, especially lipid peroxide (which is a TBARs), and antioxidant enzyme activities, but not to serum nonenzymatic total antioxidant capacity. [22][23][24][25][26][27] This is the first report showing an association between these serum oxidant/antioxidant parameters in phototherapy-treated full-term nonhemolytic hyperbilirubinemic infants. damage.…”

Section: Discussionmentioning

confidence: 99%

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Estado oxidante/antioxidante total em recém-nascidos ictéricos antes e depois da fototerapia

Ayçicek¹,

Erel²

2007

J. Pediatr. (Rio J.)

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Objective: To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.Method: Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidative stress index (OSI) and individual oxidant components: malondialdehyde (MDA), and lipid hydroperoxide levels.Results: Vitamin C, uric acid, total bilirubin and MDA concentration were significantly lower, whereas serum TOS, lipid hydroperoxide and OSI levels were significantly higher after phototherapy (p < 0.05). There were significant positive correlations between serum total bilirubin and MDA (r = 0.434, p = 0.001). Conclusions:Although the MDA level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress.J Pediatr (Rio J). 2007;83(4):319-322: Antioxidants, infant, malondialdehyde, oxidative stress, phototherapy.

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Section: Discussionmentioning

confidence: 99%

“…23 Yigit et al reported that there was no significant correlation between MDA and bilirubin levels. 22 They also reported that both bilirubin and MDA were increased in jaundiced infants, and both parameters were reduced after phototherapy, but they did not find a significant correlation between the opposite oxidant/antioxidants parameters.…”

Section: Discussionmentioning

confidence: 99%

Estado oxidante/antioxidante total em recém-nascidos ictéricos antes e depois da fototerapia

Ayçicek¹,

Erel²

2007

J. Pediatr. (Rio J.)

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“…Also in other studies found in the literature, it was reported that MDA decreased after phototherapy. It was reported in these studies that bilirubin and MDA increased together and decreased after phototherapy, however no statistical correlation was observed (5,16,17). While GSH decreased in all groups after phototherapy, it was significantly low in group 1 preterm infants after phototherapy.…”

Section: Discussionmentioning

confidence: 79%

Effects of Phototherapy on Antioxidant Status of Preterm and Term Infants with Hyperbilirubinemia

et al. 2016

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Objectives: The primary purpose of this study was to investigate the effects of phototherapy on antioxidant status of preterm and term infants with hyperbilirubinemia. Methods:Term and preterm infants were divided to three groups; group 1: 28 to < 32 weeks, group 2: 32 to < 37 weeks, and group 3: term infants hospitalized due to jaundice requiring phototherapy during the first to ninth day of life . Fifty-six infants were included in this study. Levels of serum total bilirubin, malondialdehyde, superoxide dismutase, reduced glutathione and catalase were measured before and 24 hours after phototherapy.Results: It was found that the reduced glutathione levels in group 1 including preterm infants decreased significantly after phototherapy. It was observed that levels of malondialdehyde increased significantly in term infants compared to preterm infants in group 1 and group 2. It was observed that the decreases in bilirubin and superoxide dismutase enzyme were correlated in group 2 preterm infants and group 3 term infants.Conclusions: Phototherapy did not significantly affect the antioxidant level in the present study. The fact that there was a significant decrease in glutathione peroxidase levels after phototherapy only in group 1 preterm infants suggests that more attention should be paid when phototherapy is used in this age group.

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“…Ozture et al . reported that MDA concentrations were significantly lower after PT than before PT, and no significant correlation was found between plasma MDA and plasma bilirubin concentrations before and after PT . Yiğit et al .…”

Section: Discussionmentioning

confidence: 93%

“…In contrast, MDA levels after PT were significantly higher than before PT. It was shown that plasma MDA concentrations in neonates with nonhemolytic jaundice were significantly higher than those in healthy infants . Ozture et al .…”

Section: Discussionmentioning

confidence: 98%

Ischaemia‐modified albumin levels in newborn jaundice before and after phototherapy

Erdem

Kurban

Altunhan

et al. 2011

Cell Biochemistry & Function

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The aim of our study was to assess the effect of phototherapy (PT) on ischaemia-modified albumin (IMA) and malondialdehyde (MDA) levels in hyperbilirubinemic full-term newborns. The study was performed on 36 full-term infants exposed to PT. The babies were aged 3 to 13 days. IMA and MDA levels of the babies were determined before and after PT, by a colorimetric assay. IMA levels before and after PT were found as 0.424 ± 0.290 and 0.531 ± 0.262 absorbance units, respectively. Although IMA levels after PT were slightly higher, the difference was not statistically significant (p > 0.131). MDA levels before and after PT were found as 8.4 ± 1.8 µmol/l and 9.4 ± 1.5 µmol/l, respectively. Serum MDA concentrations were significantly higher after PT than before PT (p < 0.000). In previous studies, conflicting findings have been reported about the effect of PT on oxidant and antioxidant systems. However, we have found no study investigating IMA levels in hyperbilirubinaemia in newborns before and after PT. Our results shows that PT does not affect IMA levels significantly. IMA increases as a result of oxidative stress. We believe that the lack of significant difference between our IMA levels before and after PT may resulted from hyperbilirubinaemia, which has antioxidant effect.

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How phototherapy affects the relation between serum bilirubin and plasma malondialdehyde in neonates

Cited by 7 publications

References 4 publications

Estado oxidante/antioxidante total em recém-nascidos ictéricos antes e depois da fototerapia

Estado oxidante/antioxidante total em recém-nascidos ictéricos antes e depois da fototerapia

Effects of Phototherapy on Antioxidant Status of Preterm and Term Infants with Hyperbilirubinemia

Ischaemia‐modified albumin levels in newborn jaundice before and after phototherapy

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