How predictable is the erectile function of patients with epilepsy?

Vieira, Fábio Cavalcanti de Faria; Ronsoni, Marcelo Fernando; Hohl, Alexandre; Claudino, Lúcia Sukis; Diaz, Alexandre Paim; Schwarzbold, Marcelo Libório; Guarnieri, Ricardo; Nunes, Jean Costa; Lin, Kátia; Walz, Roger

doi:10.1016/j.yebeh.2015.04.068

Cited by 3 publications

(1 citation statement)

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“…It is closely associated with aging, lifestyle, and comorbid diseases such as cardiovascular disease, hypertension, diabetes mellitus, depression, or neurological disorders including epilepsy (Wyllie 2005 ). Erectile dysfunction has been estimated to occur in up to 65% of men suffering from epilepsy and may be related to endocrine system abnormalities caused by epileptic discharges or antiepileptic drug treatment, psychiatric comorbidities, and psychosocial problems (Hamed et al 2013 ; Vieira et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice

et al. 2018

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Tadalafil, a selective phosphodiesterase type 5 inhibitor, is a long-acting oral agent for the treatment of erectile dysfunction of multiple etiologies. Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the influence of tadalafil on seizure susceptibility has not been studied so far. Therefore, the aim of the present study was to investigate the effect of tadalafil on seizure threshold as well as on the activity of some first- and second-generation antiepileptic drugs in three acute seizure tests in mice. The obtained results showed that tadalafil, at the highest dose tested (20 mg/kg), significantly decreased the threshold for the first myoclonic twitch in the intravenous pentylenetetrazole (i.v. PTZ) seizure test. It did not affect the threshold for generalized clonic seizure and forelimb tonus in the i.v. PTZ, for tonic hindlimb extension in the maximal electroshock seizure threshold test, and for psychomotor seizure in the 6-Hz-induced seizure threshold test. Tadalafil did not alter the anticonvulsant activity of any of the studied antiepileptic drugs in electrically induced seizure tests. Interestingly, tadalafil potentiated the anticonvulsant activity of clonazepam and decreased the anticonvulsant activity of oxcarbazepine in the i.v. PTZ test. These interactions were pharmacodynamic in nature, as tadalafil did not alter clonazepam and oxcarbazepine concentrations both in serum and brain tissue. Furthermore, neither tadalafil alone nor its combinations with the studied antiepileptic drugs produced any significant impairment of motor coordination (assessed in the chimney test), muscular strength (investigated in the grip-strength test), and long-term memory (assessed in the passive avoidance task). In conclusion, tadalafil may increase the risk of myoclonic seizure and decrease the anticonvulsant efficacy of oxcarbazepine. Further studies are warranted to evaluate the safety of tadalafil usage in patients with epilepsy.

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Section: Introductionmentioning

confidence: 99%