How Prepared Are We to Control Severe Acute Respiratory Syndrome in Future

Abstract

No non-human reservoirs for smallpox-and polio-viruses has contributed to the success of worldwide eradication of smallpox and a significant control of poliomyelitis. Most emerging and re-emerging viruses including SARS Coronavirus (SARS-CoV), have animal reservoirs and therefore,they impose a constant threat of host jump leading tooutbreaksin humans. It is desirable to be ready for control of infections that are caused by zoonotic pathogens, even after an outbreak has ended. This literature review is a compilation of advances made so far for diagnosis and treatment of SARS.

Enteric Pathogens of Dogs and Cats With Public Health Implications

“…Besides that, in China, there were found SARS virus like Coronaviruses in a masked palm civet and a raccoon dog, two wild carnivore species. Following sequence analysis, the human and civet viruses' origin presented 99% homology although placed in different clusters (Bhardwaj, 2013). Also, changes in virulence, tissue tropisms and interspecies transmission of CCoVs have been found and they occur due to genetic variations in structural and non-structural proteins of the virus (Guan et al, 2003;Vijgen et al, 2005).…”

Advances in developing small molecule SARS 3CLpro inhibitors as potential remedy for corona virus infection

“… 37 The key steps during the viral entry of the SARS-CoV-2 include the binding interaction of the host cells receptor, ACE2 with the spike protein of virus S protein, subsequent changes in the conformation of the S protein followed by proteolysis for the activation of the COVID-19 in the human cells. 38 In addition to that, the two replicase polyproteins, pp1a and pp1ab which are also known as the promoters for viral replication are arranged perpendicularly to one another and both of them contain three domains I, II and III. Domains I and II have similar structural β–patterns as present in picoronavirus 3C proteinases.…”