Success in early detection of harmful stress, mental ill-health, and suicidal behaviour is substantially dependent on system solutions at the macro level. Suicide prevention interventions and strategies can only be effective if cross-disciplinary knowledge and skills, at different stages of the suicidal process and on different vulnerable groups are combined. In this chapter, traditionally well-known vulnerable groups, such as people with depression and alcohol misuse, are discussed at different stages of the suicidal process, in order to increase early detection. Early recognition is also important in demographic groups that have been neglected to date in suicide prevention, such as mothers with pre-natal and post-natal mental disorders, persons with diabetes mellitus, spinal cord injury disabilities and adult childhood cancer survivors, as well as young vulnerable people for whom harmful stress can be a suicidal trigger. In regard to the implementation and process optimization of individual interventions, lessons from management and, in particular, from social marketing, can provide a key contribution.