How radiolysis impacts astatine speciation?

Ghalei, Mohammad; Khoshouei, Parastoo Mahdi; Vandenborre, Johan; Guérard, François; Blain, Guillaume; Zarei, Mojtaba; Haddad, Férid; Fattahi, Massoud

doi:10.1016/j.radphyschem.2022.110224

Cited by 3 publications

(2 citation statements)

References 21 publications

(35 reference statements)

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“…In a recent publication it is recommended that Chloroform Eluate after dry distillation is washed with water 15 . In the present study, simply applying equal phase volumes of MilliQ water and Chloroform Eluate and contacting briefly results in a distribution ratio of 0.02, in good agreement with the results in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Behaviour, use and safety aspects of astatine-211 solvated in chloroform after dry distillation recovery

Aneheim,

Hansson,

Timperanza

et al. 2024

Sci Rep

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Targeted alpha therapy of disseminated cancer is an emerging technique where astatine-211 is one of the most promising candidate nuclides. Astatine-211 can be produced in medium energy cyclotrons by alpha particle bombardment of natural bismuth. The produced astatine is then commonly recovered from the irradiated solid target material through dry distillation. The dry distillation process often includes elution and solvation of condensed astatine with chloroform, forming Chloroform Eluate. In this work the handling and safe use of the high activity concentration Chloroform Eluate has been investigated. Correctly performed, evaporation of Chloroform Eluate results in a dry residue with complete recovery of the astatine. The dry residue can then serve as a versatile starting material, using appropriate oxidizing or reducing conditions, for subsequent downstream chemistry. However, it has been found that when evaporating the Chloroform Eluate, astatine can be volatilized if continuing the process beyond the point of dryness. This behavior is more pronounced when the Chloroform Eluate has received a higher absorbed dose. Upon water phase contact of the Chloroform Eluate, a major part of the astatine activity becomes water soluble, leaving the organic phase. A behavior which is also dependent on dose to the solvent.

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Section: Resultsmentioning

confidence: 99%

“…In a recent publication, washing of Chloroform Eluate with water is recommended in order to remove HCl formed by radiolysis of the chloroform 15 . From the results in the present study it can, however, be concluded that this is not always advisable as this may cause major losses of activity from the organic phase.…”

Section: Discussionmentioning

confidence: 99%