In this digital era, museum as an institution increasingly incorporates virtual technology into their exhibitions and architectural elements. The application of virtual materials in museums allows sensory variations that enrich visitors' experience. A sense of realness needs to be considered in a museum environment, with virtual materials as its constituent elements that can arouse the emotional involvement of visitors. This paper investigates virtual materials' applications and a sense of realness qualities in real-virtual museum architecture. It employs a qualitative research strategy with in-depth interviews and precedent studies used as data collection techniques and content analysis as its analyzing method. Study results show that the principle of immersion to arouse a sense of realness in a real-virtual museum environment includes sensory richness, interaction, and coherence. Integrating real-virtual elements can be carried out within architectural formal and spatial elements' design. Integration with architectural formal elements includes using interactive surfaces and surface projections, while integration with architectural spatial elements includes the application of motion and audio sensors. These integrations can be implemented in architectural design by isolating virtual devices from outdoor distractions like light, sound, humidity, and temperature.