How RNAi machinery enters the world of telomerase

Laudadio, Ilaria; Carissimi, Claudia; Fulci, Valerio

doi:10.1080/15384101.2019.1609834

Cited by 7 publications

(3 citation statements)

References 131 publications

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“…RISC components like AGO2 and SND1 are known to play pivotal roles in TERC stability and function. [44][45][46] The significance of AGO2 as an important mediator of hepatocarcinogenesis is well established. Through the formation of the RISC-loading complex, AGO2 exerts its role in the progres-sion of HCC.…”

Section: The Alliance Of Telomerase and Risc In Hccmentioning

confidence: 99%

Telomerase, an Accomplice of RNA-induced Silencing Complex in Hepatocellular Carcinoma

Puttahanumantharayappa¹,

Shiragannavar²,

Gowda³

et al. 2023

Gene Expr

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Hepatocellular carcinoma (HCC) is one of the most lethal and widespread cancers in the human race. Despite its fatal attributes, there is only a limited understanding of the factors contributing to its pathogenesis at the cellular and molecular levels. Consequently, unraveling new facets involved in HCC progression is elemental for establishing novel targets and biomarkers for this disease. Over the last few years, emerging evidence signifies the role of RNA-induced silencing complex in mediating gene silencing and contributing to HCC. Recent studies also highlight the importance of human telomerase holoenzyme and its complex accessory proteins in the development of HCC. The current review encompasses the multifaceted roles of RNAinduced silencing complex and telomerase activity as well as their synergistic function in HCC.

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Section: The Alliance Of Telomerase and Risc In Hccmentioning

confidence: 99%

Telomerase, an Accomplice of RNA-induced Silencing Complex in Hepatocellular Carcinoma

Puttahanumantharayappa¹,

Shiragannavar²,

Gowda³

et al. 2023

Gene Expr

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“…When it is overexpressed, it is sufficient to enhance telomerase activity, and analyses of sRNA-seq datasets showed that terc-sRNA is detected in primary human tissues and increases in tumors as compared to control tissues [ 195 ]. It has been proposed that terc-sRNA facilitates the association between TERC and Argonaute proteins, which, in turn, have recently been showed to be necessary for the proper assembly of the telomerase complex [ 196 ].…”

Section: Terc Non-telomeric Functionsmentioning

confidence: 99%

Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies

Udroiu

Marinaccio

Sgura

2022

IJMS

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A growing number of studies have evidenced non-telomeric functions of “telomerase”. Almost all of them, however, investigated the non-canonical effects of the catalytic subunit TERT, and not the telomerase ribonucleoprotein holoenzyme. These functions mainly comprise signal transduction, gene regulation and the increase of anti-oxidative systems. Although less studied, TERC (the RNA component of telomerase) has also been shown to be involved in gene regulation, as well as other functions. All this has led to the publication of many reviews on the subject, which, however, are often disseminating personal interpretations of experimental studies of other researchers as original proofs. Indeed, while some functions such as gene regulation seem ascertained, especially because mechanistic findings have been provided, other ones remain dubious and/or are contradicted by other direct or indirect evidence (e.g., telomerase activity at double-strand break site, RNA polymerase activity of TERT, translation of TERC, mitochondrion-processed TERC). In a critical study of the primary evidence so far obtained, we show those functions for which there is consensus, those showing contradictory results and those needing confirmation. The resulting picture, together with some usually neglected aspects, seems to indicate a link between TERT and TERC functions and cellular stemness and gives possible directions for future research.

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“…Есть и небольшие точки, которые являются началом новых линий. Они соответствуют немногочисленным свидетельствам существования иных типов РНК, которые в нарисованной здесь картине пока не отражены, например, теломеразные РНК[307], рибонуклеаза P[32,308], энхансерные РНК[309] и другие функциональные РНК.Исследования последних лет значительно расширили спектр некодирующих РНК, открыв существование фрагментов больших рибонуклеотидных молекул с определенными функциями, генерируемых самыми неожиданными классами хорошо изученных ранее РНК. Так, давно отнесенные к структурным, или РНК «домашнего хозяйства» -рРНК и тРНК -являются генераторами регуляторных РНК-фрагментов.…”

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Variety of Non-Coding RNAs in Eukaryotic Genomes

Nazipova¹

2021

Math.Biol.Bioinf.

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The genomes of large multicellular eukaryotes mainly consist of DNA that encodes not proteins, but RNAs. The unexpected discovery of approximately the same number of protein genes in Homo sapiens and Caenorhabditis elegans led to the understanding that it is not the number of proteins that determines the complexity of the development and functioning of an organism. The phenomenon of pervasive transcription of genomes is finding more and more confirmation. Data are emerging on new types of RNA that work in different cell compartments, are expressed at different stages of development, in different tissues and perform various functions. Their main purpose is fine regulation of the main cellular processes. The presence of a rich arsenal of regulators that can interact with each other and work on the principle of interchangeability determines the physiological complexity of the organism and its ability to adapt to changing environmental conditions. An overview of the currently known functional RNAs expressed in eukaryotic genomes is presented here. There is no doubt that in the near future, using high-tech transcriptome technologies, many new RNAs will be identified and characterized. But it is likely that many of the expressed transcripts do not have a function, but are an evolutionary reserve of organisms.

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How RNAi machinery enters the world of telomerase

Cited by 7 publications

References 131 publications

Telomerase, an Accomplice of RNA-induced Silencing Complex in Hepatocellular Carcinoma

Telomerase, an Accomplice of RNA-induced Silencing Complex in Hepatocellular Carcinoma

Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies

Variety of Non-Coding RNAs in Eukaryotic Genomes

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