The aim of this article is to review the theoretical, empirical and practical implications related to the modus operandi of sexual offenders against children. First, the rational choice perspective in criminology, which emphasizes the decision-making of offenders, is presented. Second, the descriptive studies aimed specifically at providing information on modus operandi of sexual offenders against children are also presented. This is followed by research that investigates the links between the modus operandi of sexual offenders against children and various factors such as victim characteristics. Third, offenders' treatment as well as situational crime prevention implications in regards to modus operandi are discussed in order to highlight their respective potential for the prevention of child sexual abuse.