How should I treat a very large thrombus burden in the infarct-related artery in a young patient with an unexplained lower GI tract bleeding?

TASTE-less endpoint of 30-day mortality (and some other issues with TASTE) in evaluating the effectiveness of thrombus aspiration in STEMI: not the “evidence” to change the current practice of routine consideration of manual thrombus extraction

“…1) while a significant proportion of the all-comer population you treat may be not be trial-represented (Fig. 2) [2,33].…”

Fibrin clot properties in coronary artery ectatic disease: Pilot data from the CARE-ANEURYSM Study

“…In the present sample, coronary angiographic evaluation was supplemented with intravascular imaging employing virtual histology (VH-IVUS) [12] to visualize any accompanying atherosclerotic components and perform CAEA IVUS measurements. Scanning electron microscopy (SEM) analysis of plasma fibrin clots was performed in all study subjects and controls and was extended to the thrombi retrieved from the CAEA-culprit lesion in patients undergoing thrombectomy.…”

Single-photon emission computed tomography as a fundamental tool in evaluation of myocardial reparation and regeneration therapies

“…A 62-year-old man was admitted due to anterior ST-segment elevation acute myocardial infarction. Left anterior descending coronary artery proximal occlusion was treated successfully with thrombus aspiration (to minimize distal embolization and myocardial microcirculatory obstruction in the infarct zone) [ 104 – 106 ] and primary angioplasty with stent implantation. Six days later, consistent with the CIRCULATE-AMI Pilot Study Protocol, 30 × 10 6 standardized Wharton jelly pluripotent stem cells (50% labeled with 99m Tc-sestamibi) were administered via the infarct-related-artery using a dedicated system for transcoronary delivery of cells and cell-based products (CIRCULATE Catheter, Protected Design No 72837, Patent Office of the Republic of Poland) [ 107 ].…”