How Should We Measure Peripheral Spondyloarthritis?

Coates, Laura C.; Tillett, William

doi:10.3899/jrheum.211043

Cited by 8 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, while a recent meta-analysis showed that the diagnostic delay in axSpA is longer for females compared with males (8.8 vs 6.5 years),23–25 our analysis only observed a short difference (6.2 vs 5.6 years), which was not statistically significant. Relating to pSpA and gender differences, previous data were very scarce, and limited to non-adjusted comparisons 4 26. The evaluation of gender differences in PsA is more difficult than in axSpA due to the heterogeneity of the disease, with different articular patterns 27.…”

Section: Discussionmentioning

confidence: 99%

Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study

et al. 2022

View full text Add to dashboard Cite

ObjectivesTo investigate the influence of gender on disease outcomes in patients with spondyloarthritis (SpA), including across SpA subtypes.MethodsData from 4185 patients of 23 countries with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or psoriatic arthritis (PsA) from the Assessment of SpondyloArthritis International Society (ASAS)-perSpA study were analysed. Associations between gender and disease activity (Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Score (BASDAI), C-reactive protein (CRP)), function (Bath Ankylosing Spondylitis Functional Index (BASFI)) and overall health (ASAS Health Index (ASAS HI), European Quality of Life Five Dimension (EQ-5D)) outcomes were investigated. Multilevel multivariable linear mixed models adjusted for relevant confounders (and stratified by disease subtype in case of a relevant interaction) were used.ResultsIn total, 65%, 10% and 25% of patients had axSpA, pSpA and PsA, respectively. axSpA was more frequent in males (68%), whereas pSpA and PsA were more frequent in females (53% and 52%, respectively). A significant interaction between gender and disease subtype was found for ASDAS, BASDAI and BASFI. While being female independently contributed to higher BASDAI across the three disease subtypes (with varying magnitude), female gender was only associated with higher ASDAS in pSpA (β (95% CI): 0.36 (0.15 to 0.58)) and PsA (0.25 (0.12 to 0.38)) but not in axSpA (0.016 (−0.07 to 0.11)). No associations were observed between gender and CRP levels. Female gender was associated with higher ASAS HI and EQ-5D, without differences across disease subtype.ConclusionFemale gender is associated with less favourable outcome measures across the SpA spectrum. However, while female gender influences BASDAI across the three subtypes, ASDAS is associated with gender only in pSpA and PsA but not in axSpA. Therefore, ASDAS is an appropriate instrument both for females and males with axSpA.

show abstract

Section: Discussionmentioning

confidence: 99%

Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Delayed diagnosis can be a critical issue in primary care. The possibility of undifferentiated peripheral SpA should always be considered in patients presenting with acute-onset joint symptoms of unknown origin [ 3 ]. Patients should be referred to a rheumatologist to ensure an effective early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…should always be considered in patients presenting with acute-onset joint symptoms of unknown origin [3]. Patients should be referred to a rheumatologist to ensure an effective early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Undifferentiated peripheral spondyloarthritis (SpA) and septic arthritis are two distinct differential diagnoses in patients with acute monoarthritis [ 1 ]. Peripheral SpA is inflammatory arthritis that affects the joints of the upper and lower limbs and the spine [ 2 , 3 ]. Among peripheral SpAs, undifferentiated SpA is challenging to diagnose, and various diseases should be differentiated [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The duration of joint pain and the risk factors for septic arthritis such as age, immunological conditions, and orthopedic surgeries, should be considered [ 5 ]. Ultrasound and magnetic resonance imaging (MRI) is useful for detecting inflamed parts such as the joints' synovium, tendon, and other connective tissues [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differentiating Between Undifferentiated Peripheral Spondyloarthritis From Septic Arthritis: A Case Report

Ohta¹,

Sano²

2023

Cureus

View full text Add to dashboard Cite

Undifferentiated peripheral spondyloarthritis (SpA) and septic arthritis are two distinct differential diagnoses for patients with acute-onset monoarthritis. Effective history-taking and thorough physical examination are essential to differentiate between these two diseases. Precise follow-up can be critical for diagnosing undifferentiated peripheral SpA. Herein, we report our experience with two cases that required differentiation between undifferentiated peripheral SpA and septic arthritis. This case series shows the importance of ruling out septic arthritis promptly and considering the possibility of undifferentiated peripheral PsA based on clinical findings and imaging tests.

show abstract

37/w mit unklarer einseitiger Kniegelenksschwellung

Köhm

2021

Internist

View full text Add to dashboard Cite

How Should We Measure Peripheral Spondyloarthritis?

Abstract: Spondyloarthritis (SpA) is recognized as an overarching spectrum of disease characterized by axial SpA (axSpA), peripheral arthritis, enthesitis, and dactylitis. Despite significant overlap, patients are often characterized as having predominantly peripheral or axial involvement.

Cited by 8 publications

References 10 publications

Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study

Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study

Differentiating Between Undifferentiated Peripheral Spondyloarthritis From Septic Arthritis: A Case Report

37/w mit unklarer einseitiger Kniegelenksschwellung

Contact Info

Product

Resources

About