How smart do biomaterials need to be? A translational science and clinical point of view

Holzapfel, Boris Michael; Reichert, Johannes C.; Schantz, Jan‐Thorsten; Gbureck, Uwe; Rackwitz, Lars; Nöth, Ulrich; Jakob, Franz; Rudert, Maximilian; Groll, Jürgen; Hutmacher, Dietmar W.

doi:10.1016/j.addr.2012.07.009

Cited by 474 publications

(312 citation statements)

References 320 publications

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“…In the future, this problem has to be approached from the perspective of the nature of the implant material the surgeon works with [30]. In orthopaedic tumour surgery, in particular, a paradigm shift is needed from surgical concepts to replace tissues with inert metallic implants to more biological approaches that focus on repair and reconstitution of tissue structure and function [31].…”

Section: Discussionmentioning

confidence: 99%

Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours

Holzapfel

Pilge

Prodinger

et al. 2014

International Orthopaedics (SICOT)

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Purpose We sought to analyse clinical and oncological outcomes of patients after guided resection of periacetabular tumours and endoprosthetic reconstruction of the remaining defect.Methods From 1988 to 2008, we treated 56 consecutive patients (mean age 52.5 years, 41.1 % women). Patients were followed up either until death or February 2011 (mean follow up 5.5 years, range 0.1-22.5, standard deviation ± 5.3). Kaplan-Meier analysis was used to estimate survival rates.Results Disease-specific survival was 59.9 % at five years and 49.7 % at ten and 20 years, respectively. Wide resection margins were achieved in 38 patients, whereas 11 patients underwent marginal and seven intralesional resection. Survival was significantly better in patients with wide or marginal resection than in patients with intralesional resection (p=0.022). Survival for patients with secondary tumours was significantly worse than for patients with primary tumours (p=0.003). In 29 patients (51.8 %), at least one reoperation was necessary, resulting in a revision-free survival of 50.5 % at five years, 41.1 % at ten years and 30.6 % at 20 years. Implant survival was 77.0 % at five years, 68.6 % at ten years and 51.8 % at 20 years. A total of 35 patients (62.5 %) experienced one or more complications after surgery. Ten of 56 patients (17.9 %) experienced local recurrence after a mean of 8.9 months. The mean postoperative Musculoskeletal Tumor Society (MSTS) score was 18.1 (60.1 %). Conclusion The surgical approach assessed in this study simplifies the process of tumour resection and prosthesis implantation and leads to acceptable clinical and oncological outcomes.

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Section: Discussionmentioning

confidence: 99%

Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours

Holzapfel

Pilge

Prodinger

et al. 2014

International Orthopaedics (SICOT)

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“…Stainless steel (SUS 316L SS an austenitic stainless steel), cobalt alloys, pure Ti and Ti-6al-4v are mainly used for biomedical applications [59] .…”

Section: Metallic Biomaterialsmentioning

confidence: 99%

“…Polyglycolic acid (PGA), polylactide (PLA), polydioxanone (PDS) are mainly used as resorbable bone fixation devices or as suture materials [59] . For surgical wound repair fibrin glue is used as tissue adhesive [62] .…”

Section: Polymersmentioning

confidence: 99%

Biomimetic Materials in Dentistry

Ali¹,

Saraf²,

Patil³

et al. 2017

Res. Rev. J Mat. Sci

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“…Smart instrumentation requires attention to materials, for example when Holzapfel et al [159] ask "How smart do biomaterials need to be? …".…”

Section: Technologiesmentioning

confidence: 99%

Smart and green interfaces: From single bubbles/drops to industrial environmental and biomedical applications

Dutschk

Karapantsios

Liggieri

et al. 2014

Advances in Colloid and Interface Science

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Interfaces can be called Smart and Green (S&G) when tailored such that the required technologies can be implemented with high efficiency, adaptability and selectivity. At the same time they have also to be eco-friendly, i.e. products must be biodegradable, reusable or simply more durable. Bubble and drop interfaces are in many of these smart technologies the fundamental entities and help develop smart products of the everyday life.Significant improvements of these processes and products can be achieved by implementing and manipulating specific properties of these interfaces in a simple and smart way, in order to accomplish specific tasks. The severe environmental issues require in addition attributing ecofriendly features to these interfaces, by incorporating innovative , or, sometime, recycle materials and conceiving new production processes which minimize the use of natural resources and energy. Such concept can be extended to include important societal challenges related to support a sustainable development and a healthy population.The achievement of such ambitious targets requires the technology research to be supported by a robust development of theoretical and experimental tools, needed to understand in more details the behavior of complex interfaces. A wide but not exhaustive review of recent work concerned with green and smart interfaces is presented, addressing different scientific and technological fields. The presented approaches reveal a huge potential in relation to various technological fields, such as nanotechnologies, biotechnologies, medical diagnostics, new or improved materials.

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How smart do biomaterials need to be? A translational science and clinical point of view

Cited by 474 publications

References 320 publications

Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours

Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours

Biomimetic Materials in Dentistry

Smart and green interfaces: From single bubbles/drops to industrial environmental and biomedical applications

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