How the Study of
            <i>Listeria Monocytogenes</i>
            has Led to New Concepts in Biology

Rolhion, Nathalie; Cossart, Pascale

doi:10.2217/fmb-2016-0221

Cited by 44 publications

(36 citation statements)

References 133 publications

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“…The ability of this pathogen to causes disease requires entering epithelial cells, escaping the phagosome, and accessing the cytosol to replicate therein. L. monocytogenes has been extensively studied with respect to its adaptation to an intracellular niche, and this research has led to many important discoveries that impact biological sciences beyond bacteriology (121). Throughout its infection cycle, L. monocytogenes uses many virulence factors that are tightly controlled by the bacterium.…”

Section: Listeria Monocytogenesmentioning

confidence: 99%

Taming the Triskelion: Bacterial Manipulation of Clathrin

Latomanski

Newton

2019

Microbiol Mol Biol Rev

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SUMMARYThe entry of pathogens into nonphagocytic host cells has received much attention in the past three decades, revealing a vast array of strategies employed by bacteria and viruses. A method of internalization that has been extensively studied in the context of viral infections is the use of the clathrin-mediated pathway. More recently, a role for clathrin in the entry of some intracellular bacterial pathogens was discovered. Classically, clathrin-mediated endocytosis was thought to accommodate internalization only of particles smaller than 150 nm; however, this was challenged upon the discovery thatListeria monocytogenesrequires clathrin to enter eukaryotic cells. Now, with discoveries that clathrin is required during other stages of some bacterial infections, another paradigm shift is occurring. There is a more diverse impact of clathrin during infection than previously thought. Much of the recent data describing clathrin utilization in processes such as bacterial attachment, cell-to-cell spread and intracellular growth may be due to newly discovered divergent roles of clathrin in the cell. Not only does clathrin act to facilitate endocytosis from the plasma membrane, but it also participates in budding from endosomes and the Golgi apparatus and in mitosis. Here, the manipulation of clathrin processes by bacterial pathogens, including its traditional role during invasion and alternative ways in which clathrin supports bacterial infection, is discussed. Researching clathrin in the context of bacterial infections will reveal new insights that inform our understanding of host-pathogen interactions and allow researchers to fully appreciate the diverse roles of clathrin in the eukaryotic cell.

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Section: Listeria Monocytogenesmentioning

confidence: 99%

Taming the Triskelion: Bacterial Manipulation of Clathrin

Latomanski

Newton

2019

Microbiol Mol Biol Rev

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“…Listeria monocytogenes es un patógeno intracelular facultativo cuya expresión de factores de virulencia están controlados por múltiples mecanismos regulados por el ARN 34 . Su patogenia íntima es compleja e incluye: adhesión a la célula hospedera e invasión (internalización), su fuga de las vacuolas fagocíticas, multiplicación intracelular y movilidad que le lleva propagarse de célula a célula 13,35 .…”

Section: Patogeniaunclassified

Panorama de la infección por Listeria monocytogenes

Rodríguez-Auad¹

2018

Rev. chil. infectol.

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Overview of Listeria monocytogenes infection Listeriosis is an uncommon but potentially serious infection caused by Listeria monocytogenes. The main route of transmission is through the consumption of contaminated food. It generally affects elderly people, pregnant women and immunosuppressed hosts, although cases are also seen in immunocompetent adults and children. Listeria monocytogenes is a short, anaerobic, non-spore-forming gram-positive bacillus that causes a narrow zone of hemolysis in blood agar. It is a facultative intracellular pathogen, and therefore it shows a complex pathogenesis. This bacterium has the ability to cross the intestinal barrier, the placenta and the blood-brain barrier producing gastroenteritis, maternal-fetal infections and meningoencephalitis. It is most commonly diagnosed from a positive culture of a sterile site. The treatment of choice includes the use of intravenous ampicillin alone or in combination with gentamicin.

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“…Microbes are part of a Faustian microcosm, teaching us how the macrocosm, nature, is constructed and persists in functioning. A paradigmatic example is how the study of Listeria monocytogenes has led to new concepts in biology (Radoshevich & Cossart, ; Rolhion & Cossart, ). In this MicroReview, we will address the antibiotic resistance in L. monocytogenes .…”

Section: Introductionmentioning

confidence: 99%

Ecogenetics of antibiotic resistance in Listeria monocytogenes

Baquero

Lanza

Duval

et al. 2020

Molecular Microbiology

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The acquisition process of antibiotic resistance in an otherwise susceptible organism is shaped by the ecology of the species. Unlike other relevant human pathogens, Listeria monocytogenes has maintained a high rate of susceptibility to the antibiotics used for decades to treat human and animal infections. However, L. monocytogenes can acquire antibiotic resistance genes from other organisms’ plasmids and conjugative transposons. Ecological factors could account for its susceptibility. L. monocytogenes is ubiquitous in nature, most frequently including reservoirs unexposed to antibiotics, including intracellular sanctuaries. L. monocytogenes has a remarkably closed genome, reflecting limited community interactions, small population sizes and high niche specialization. The L. monocytogenes species is divided into variants that are specialized in small specific niches, which reduces the possibility of coexistence with potential donors of antibiotic resistance. Interactions with potential donors are also hampered by interspecies antagonism. However, occasional increases in population sizes (and thus the possibility of acquiring antibiotic resistance) can derive from selection of the species based on intrinsic or acquired resistance to antibiotics, biocides, heavy metals or by a natural tolerance to extreme conditions. High‐quality surveillance of the emergence of resistance to the key drugs used in primary therapy is mandatory.

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How the Study of Listeria Monocytogenes has Led to New Concepts in Biology

Cited by 44 publications

References 133 publications

Taming the Triskelion: Bacterial Manipulation of Clathrin

Taming the Triskelion: Bacterial Manipulation of Clathrin

Panorama de la infección por Listeria monocytogenes

Ecogenetics of antibiotic resistance in Listeria monocytogenes

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