The objective of this study was to compare central systolic blood pressure (cSBP) and augmentation index (AIx) from two recently introduced devices, Omron HEM-9000 (OM) and Arteriograph (AG), not using a transfer function with those of the widely used SphygmoCor (SC) calibrated on brachial blood pressure like OM. Random-order manufacturer-recommended measurements using SC and OM by radial tonometry and AG were taken on the left arm in 35 men (54±10 years) after 5 min supine rest. Results are means (95% confidence interval) of differences using paired t-tests. cSBP by OM was 4.1 (1.0-7.1) mm Hg higher than by AG. Both OM and AG estimated the mean cSBP to be significantly higher than did SC (114.8 mm Hg) by 12.5 (10.3-14.7) and 8.6 (4.9-12.3) mm Hg, respectively, although closely correlating with SC (r¼0.9). Calibrating SC with diastolic blood pressure (DBP) and more accurate mean arterial pressure (as DBP+0.4ÂPP) resulted in significantly higher cSBP statistically not different from AG's cSBP: 0.9 (À1.1 to +2.9)mm Hg, and closer to OM's: 5.1 (3.4-6.8)mm Hg. Radial AIx from SC and OM disagreed by 3 (0.7-5.4)%, and correlated (r¼0.8) with AG's brachial AIx. AG's aortic AIx was 7.9 (5.7-10.2)% higher than SC's, but closely correlated (r¼0.9). Clinically significant, higher cSBP measured by AG, OM and more accurately calibrated SC adds to previous data suggesting that SC measurements by classic calibration underestimate cSBP. Invasive studies involving all three devices would be more illuminating.
INTRODUCTIONCentral blood pressure (cSBP) and indices of wave reflections have become relevant to cardiovascular risk stratification and hypertension management. The primary organs targeted by hypertensive damage (heart, brain and kidneys) may be exposed more closely to aortic blood pressure (BP) and pulsations rather than that estimated by traditionally measured brachial pressures. 1 Moreover, antihypertensive medications may affect central and peripheral pressures differently 2 which could influence drug efficacy and risk reduction. 3 Our previous data from the CAFE study suggested that one drug class and combination produced greater central but not peripheral BP change based on SphygmoCor (SC). 2 There are still few large cohort studies comparing the prospective value of central versus peripheral (brachial) pressures, but a number of small to medium size studies have demonstrated the value of invasively measured central systolic and pulsating pressures prospectively. 4 Large trials demand quick non-invasive measurement of central pressures.