Health is an information rich and complex environment, which makes it essential to implement interoperability in different health organizations and the consequent homogeneity among Health Information Systems (HIS). The Agency for the Integration, Dissemination and Archiving of Medical and Clinical Information (AIDA) is a consistent agent monitoring platform capable of guaranteeing the automation of information as well as the interoperability and integration of HIS. This platform was designed as a solution to the information islands that are commonly found in hospital systems, and it is currently being used in several hospitals throughout Portugal. However, like any technological innovation, the solution requires a constant health technology assessment (HTA) to ensure the absence of obsolescence and a continued efficiency and security of the platform. Hence, this article focuses on the relevance and the need for vigilance, culminating in the restructuring of certain intelligent agents that make up the AIDA platform.