Small and medium-sized enterprises(SMEs)are important promoters of national economic development, how to promote the sustainable development of SMEs has significant theoretical and practical significance. The exogenous growth theory points out that network ties have become an important way for SMEs to obtain external resources and promote enterprise growth. However, the existing research ignores the impact of network ties on the business model innovation of SMEs. Focusing on this theoretical gap, this study constructs a "network ties -business model innovation -enterprise growth" model to explore the influence mechanism of five network ties of SMEs: customer ties, supplier ties, competitor ties, political ties and knowledge ties on business model innovation and enterprise growth. Based on a questionnaire survey of 234 SMEs in Chengdu, China, the research hypothesis was tested using PLS-SEM and fsQCA analysis. The PLS-SME results show that customer, supplier, competitor, and knowledge ties of SMEs have a significant positive effect on business model innovation, and business model innovation has a significant positive effect on enterprise growth. In addition, business model innovation plays a mediating role between supplier ties, competitor ties, knowledge ties, and enterprise growth. The fsQCA results show that three paths lead to the high-level business model innovation of SMEs, among which customer ties, supplier ties, com-petition ties, and knowledge ties are the necessary conditions, and three paths lead to high-level growth of SMEs, among which business model innovation is the most core necessary condition. Different combinations of business model innovation and customer ties, customer ties, supplier ties, competition ties, and knowledge ties lead to the growth of SMEs. Overall, the analysis results of PLS-SEM are consistent with those of fsQCA. The conclusion of this study not only enriches the relevant research of social network theory and business model innovation but also provides practical enlightenment for SMEs managers to use network ties to realize business model innovation and promote enterprise growth.INDEX TERMS SMEs, network ties, business model innovation, enterprise growth, PLS-SEM, fsQCA.