How to decrease mortality in necrotising pancreatitis?

Abstract

A new method for the treatment of chronic pancreatitis by introducing into arterial bed of pancreas or a regional arterial bed pancreas suspension of hydrocortisone. Objective: To provide local intensification anti-inflammatory effects, reducing the risk of systemic side effects. Material and methods: Endovascular treatment of 30 patients (19 males (63,3%) and 11 women (36.7%), the average age of 50.7 years. Organ (gastroduodenal artery) or regional (celiac trunk) infusion of a suspension of hydrocortisone. Indications e ineffectiveness of conservative therapy, recurrent of pain.Clinical evaluation of the dynamics of abdominal pain during the infusion, within 1 month and 6 months. A score of pain, where 0-his absence, the maximum intensity of 5.Studied indices of tissue blood flow in the stomach by a method rheoarteriogastrography at baseline, at the middle and at the end of long arterial infusion suspension of hydrocortisone in pool celiac trunk, n = 15.We studied the performance of the specific density of the pancreatic tissue during the treatment. Results: Severe pain at the time of admission to the surgical hospital. After endovascular treatment of pain intensity reduced to 0,34 AE 0,19 points.Flow condition in the stomach without ischemic changes during and after treatment.According to the CT study noted a decrease in the size of the pancreas, the restoration of the specific density of the parenchyma to normal values. Conclusions: Endovascular treatment method allows HP to stop inflammation, affect tissue fibrosis and the loss of its basic functions.