How to detect and track chronic neurologic sequelae of COVID-19? Use of auditory brainstem responses and neuroimaging for long-term patient follow-up

Ogier, Michaël; Andéol, Guillaume; Sagui, Emmanuel; Bo, Grégory Dal

doi:10.1016/j.bbih.2020.100081

Cited by 57 publications

(64 citation statements)

References 63 publications

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“…ACE2 facilitates the conversion of angiotensin II to angiotensin and is widely distributed in nose, lungs, liver, kidneys, capillary endothelium, and brain in normal human physiology. 11 12 13 …”

Section: The Cns Complications and Possible Mechanisms Of Covid-19mentioning

confidence: 99%

“… 13 Ogier also suggests follow-up screening with cognitive evaluation, brain imaging (MRI, positron emission tomography), and auditory brainstem responses would help to detect brain dysfunction of COVID-19 patients. 12 Overall, long-term follow-up study for those survivors may reveal new neurologic consequences of COVID-19 such as cognitive decline, accelerated aging, and dementia in the future.…”

Section: The Cns Complications and Possible Mechanisms Of Covid-19mentioning

confidence: 99%

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Coping with Dementia in the Middle of the COVID-19 Pandemic

et al. 2020

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Multiple neurological complications have been associated with the coronavirus disease-19 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. This is a narrative review to gather information on all aspects of COVID-19 in elderly patients with cognitive impairment. First, the following three mechanisms have been proposed to underlie the neurological complications associated with COVID-19: 1) direct invasion, 2) immune and inflammatory reaction, and 3) hypoxic brain damage by COVID-19. Next, because the elderly dementia patient population is particularly vulnerable to COVID-19, we discussed risk factors and difficulties associated with cognitive disorders in this vulnerable population. We also reviewed the effects of the patient living environment in COVID-19 cases that required intensive care unit (ICU) care. Furthermore, we analyzed the impact of stringent social restrictions and COVID-19 pandemic-mediated policies on dementia patients and care providers. Finally, we provided the following strategies for working with elderly dementia patients: general preventive methods; dementia care at home and nursing facilities according to the activities of daily living and dementia characteristics; ICU care after COVID-19 infection; and public health care system and government response. We propose that longitudinal follow-up studies are needed to fully examine COVID-19 associated neurological complications, such as dementia, and the efficacy of telemedicine/telehealth care programs.

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Section: The Cns Complications and Possible Mechanisms Of Covid-19mentioning

confidence: 99%

Section: The Cns Complications and Possible Mechanisms Of Covid-19mentioning

confidence: 99%

Coping with Dementia in the Middle of the COVID-19 Pandemic

et al. 2020

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“…15 MS'te görülen demiyelinizasyon, oligodendrositlerin ölümü, yoğun bağışıklık tepkisi veya enfekte sinir hücrelerinden inflamatuar moleküllerin salınmasından kaynaklanabilir. 16 Yeni SARS-CoV-2'nin nöroinvaziv özelliğinin beyin fonksiyonlarında ne yaptığı ve bu durumun nasıl takip edilebileceği henüz bilinmemektedir. Bu nedenle Ogier ve ark., COVID-19'un santral sinir sisteminde geç dönem etkilerinin, önceki CoV'larda ve diğer nörotropik virüslerde olduğu gibi noninvaziv olması nedeni ile işitsel beyin sapı yanıtlarıyla takip edilmesini önermektedirler.…”

Section: Koronavi̇rüs Ai̇lesi̇ni̇n Nörotropi̇k öZelli̇kleri̇unclassified

“…Bu nedenle Ogier ve ark., COVID-19'un santral sinir sisteminde geç dönem etkilerinin, önceki CoV'larda ve diğer nörotropik virüslerde olduğu gibi noninvaziv olması nedeni ile işitsel beyin sapı yanıtlarıyla takip edilmesini önermektedirler. 16…”

Section: Koronavi̇rüs Ai̇lesi̇ni̇n Nörotropi̇k öZelli̇kleri̇unclassified

“…23 Ancak bu durum, daha çok ağır ve aktif hastalarda belirgindir ve çoğunlukla ölümle sonuçlanabilir. 16,23 CoV ailesi ile ilgili yapılan çalışmalar sayesinde, CoV-2 virüsünün de hücreye girmek için "angiotensin converting enzyme-2 (ACE-2)" kullandığı belirlenmiştir. 16 Bu enzim sadece akciğer hücrelerinde değil, aynı zamanda endotel hücreleri, enterositler, böbrek hücreleri, hepatositler, düz kaslar, sinir hücreleri ve dolayısıyla santral ve periferik sinir sistemi de dâhil vücuttaki her organda bulunmaktadır.…”

Section: Covid-19'da Olasi Odyovesti̇büler Si̇stem Etki̇si̇ni̇n Patofi̇zyolunclassified

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COVID-19 and Audiovestibular System

Özer¹,

Özer²,

Yavûz³

2020

KBB ve BBC Dergisi

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Koronavirüs [coronavirus (CoV)], soğuk algınlığından pnömoni, solunum yetmezliği ve ölüm olmak üzere çok daha şiddetli alt solunum yolu hastalıklarına kadar geniş bir klinik spektruma neden olabilen tek zincirli bir RNA virüstür. 1 Dünya Sağlık Örgütü, bu salgını Çin'de Aralık 2019 tarihinde ortaya çıktığı için yeni koronavirüs hastalığı-2019 [novel coronavirus disease-2019 (COVID-19)] olarak tanımlamıştır. Bu hastalığa neden olan virüsün referans adı ise, Dünya Sağlık Örgütü tarafından şiddetli akut solunum sendromu-koronavirüs-2 [severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)] olarak belirlenmiştir. 2 Tüm dünyada 2 Haziran 2020 tarihi itibarıyla toplam 6.194.533 vaka tespit edilen bu pandemik hastalıkta en sık görülen bulgular; ateş, kuru öksürük ve yorgunluk olarak bildirilmiştir. 3 Anoreksi, nefes darlığı, balgam ve miyalji vakaların %25'inden fazlasında bildirilmekle beraber, bulantı ve ishal çok daha az görülmektedir. 4 Ayrıca daha az görülmekle beraber, boğaz ağrısı, rinore, burun tıkanıklığı, tonsillerde hiperemi, servikal lenfadenit, hiposmi/anosmi ve tat bozuklukları ile baş dönmesi/dengesizlik, kulak burun boğaz uzmanının COVID-19 hastalarını incelerken karşılaşabileceği belirtilerdir. 5 Solunum sistemi CoV üzerine 40 yıl süren araştırmalar, bu virüslerin nörolojik hastalık semptomları olmasa bile sinir sistemine girme ve kalıcı beyin en-COVID-19 ve Odyovestibüler Sistem COVID-19 and Audiovestibular System Fulya ÖZER a , Cem ÖZER a , Haluk YAVUZ a a

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The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning

Erausquin

Snyder

Carrillo

et al. 2021

Alzheimer's & Dementia

173

154

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Introduction:The increasing evidence of SARS-CoV-2 impact on the central nervous system (CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's disease (AD), and other dementia.Methods: The Alzheimer's Association and representatives from more than 30 countries-with technical guidance from the World Health Organization-have formed an international consortium to study the short-and long-term consequences of SARS-CoV-2 on the CNS-including the underlying biology that may contribute to AD and other dementias. This consortium will link teams from around the world covering more than 22 million COVID-19 cases to enroll two groups of individuals including people with disease, to be evaluated for follow-up evaluations at 6, 9, and 18 months, and people who are already enrolled in existing international research studies to add additional measures and markers of their underlying biology. Conclusions:The increasing evidence and understanding of SARS-CoV-2's impact on the CNS raises key questions on the impact for risk of later life cognitive decline, AD, and other dementia. This program of studies aims to better understand the long-term consequences that may impact the brain, cognition, and functioning-including the underlying biology that may contribute to AD and other dementias.

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How to detect and track chronic neurologic sequelae of COVID-19? Use of auditory brainstem responses and neuroimaging for long-term patient follow-up

Cited by 57 publications

References 63 publications

Coping with Dementia in the Middle of the COVID-19 Pandemic

Coping with Dementia in the Middle of the COVID-19 Pandemic

COVID-19 and Audiovestibular System

The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning

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