How to Diagnose Exercise Induced Asthma?

Ali, Zarqa

doi:10.5812/asjsm.34776

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…The BTS Guideline on Pulmonary Rehabilitation in Adults (48) proposed that those with chronic respiratory disease should be referred to pulmonary rehabilitation, and the routine referral of patients with asthma to pulmonary rehabilitation is not recommended based on inadequate clinical evidence. Asthmatics can be anxious about exerciseinduced bronchoconstriction (EIB) (49)(50)(51)(52), which is why some prefer a sedentary lifestyle and avoid physical activity to deter asthmatic exacerbation (53,54). Nevertheless, the increasing amount of published research proved that asthmatic patients could benefit from regular exercise training (18); the same effectiveness emerged in patients with exercise-induced asthma (55)(56)(57).…”

Section: Discussionmentioning

confidence: 99%

Effects of continuous aerobic exercise on lung function and quality of life with asthma: a systematic review and meta-analysis

Wu¹,

Gao²,

Lian³

2020

J Thorac Dis

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Background: Despite the obvious benefits of aerobic exercise for asthmatic patients, controversies persist.The current study evaluated the effectiveness of continuous aerobic exercise on lung function and quality of life of asthmatic patients. Methods: We searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials databases up to May 2019 and included randomized controlled trials (RCTs) of asthmatic patients intervened with whole body continuous aerobic exercise (moderate intensity, at least 20 minutes and two times a week, over a minimum period of four weeks), in which the endpoint measures were lung function and asthmarelated quality of life. A fixed-effects model (I 2 ≤50%)or random-effects model (I 2 >50%) was applied to calculate the pooled effects according to the I 2 -and Chi-squared (χ 2 ) test, funnel plots were quantified to present publication bias, and a P value <0.05 was statistically significant. Results: Eventually, 22 trials conformed to the selection criteria. In the aerobic exercise group, the forced expiratory volume improved in one second (FEV1) (I 2 =10.2%, WMD: 0.12, P=0.011), peak expiratory flow (PEF) (I 2 =87.3%, WMD: 0.66, P=0.002), forced vital capacity (FVC) (I 2 =0.0%, WMD: 0.18, P<0.001), FVC/predict (I 2 =3.9%, WMD: 4.3, P=0.014), forced expiratory flow between 25% and 75% of vital capacity (FEF 25-75% ) (I 2 =0.0%, WMD: 9.6, P=0.005), Asthma Quality of Life Questionnaire (AQLQ) (I 2 =0.0%, WMD: 0.20, P=0.002), and Pediatric Asthma Quality of life Questionnaire (PAQLQ) (I 2 =72.1%, WMD: 0.81, P<0.001), respectively, while no statistical significance existed in FEV1%predict (I 2 =36.0%, WMD: 0.68, P=0.312) and FEV1/FVC ratio (I 2 =0.0%, WMD: 0.27, P=0.443) compared with the control group. When the exercise mode was taken into account, we observed significant improvement in FEV1, PEF, and FVC in the swimming (P<0.05) or indoor treadmill (P<0.05) training group.Conclusions: Our meta-analysis proved that regular continuous aerobic exercise benefits asthma patients on FEV1, PEF, FVC, FVC%pred, FEF 25-75% , and quality of life, and was well tolerated, while there were no improvements in FEV1%pred and FEV1/FVC%. As such, swimming and treadmill training may be appropriate options.

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Section: Discussionmentioning

confidence: 99%

Effects of continuous aerobic exercise on lung function and quality of life with asthma: a systematic review and meta-analysis

Wu¹,

Gao²,

Lian³

2020

J Thorac Dis

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“…34 Third, the MCT may not be appropriate for diagnosing exercise-induced bronchoconstriction (EIB) compare to field exercise challenge test. 31 35 However, there was less chance of underdiagnosis of current asthma, because the prevalence of EIB from this study was only 3.5%, and about one third of EIB showed BHR. Fourth, although there might have been some patients who had negative BHR in response to asthma medication within 12 months, the number of subjects who had been treated for asthma within the last 12 months was very small, 156 out of total 4,791 (3.3%).…”

Section: Discussionmentioning

confidence: 70%

Current Asthma Prevalence Using Methacholine Challenge Test in Korean Children from 2010 to 2014

et al. 2021

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Background Most epidemiological studies depend on the subjects' response to asthma symptom questionnaires. Questionnaire-based study for childhood asthma prevalence may overestimate the true prevalence. The aim of this study was to investigate the prevalence of “Current asthma” using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and methacholine challenge test in Korean children. Methods Our survey on allergic disease included 4,791 children (age 7–12 years) from 2010 to 2014 in Korean elementary schools. Bronchial hyperresponsiveness (BHR) was defined as provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (FEV1) (PC20) ≤ 16 mg/mL. “Current asthma symptoms” was defined as positive response to “Wheezing, current,” “Treatment, current,” or “Exercise, current.” “Current asthma” was defined when the subjects with “Current asthma symptoms” showed BHR on the methacholine challenge test or had less than 70% of predicted FEV1 value. Results The prevalence of “Wheezing, ever,” “Wheezing, current,” “Diagnosis, ever,” “Treatment, current,” “Exercise, current,” and “Current asthma symptoms” was 19.6%, 6.9%, 10.0%, 3.3%, 3.5%, and 9.6%, respectively, in our cross-sectional study of Korean elementary school students. The prevalence of BHR in elementary school students was 14.5%. The prevalence of BHR in children with “Wheezing, ever,” “Wheezing, current,” “Diagnosis, ever,” “Treatment, current,” and “Exercise, current” was 22.3%, 30.5%, 22.4%, 28.8%, and 29.9%, respectively. BHR was 26.1% in those with “Current asthma symptoms.” The prevalence of “Current asthma” was 2.7%. Conclusions Our large-scale study provides 2.7% prevalence of current asthma in Korean elementary school children. Since approximately one third of the children who have “Current asthma symptoms” present BHR, both subjective and objective methods are required to accurately predict asthma in subjects with asthma symptoms.

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Section: Methodsmentioning

confidence: 99%

“…The spirometry was repeated after the cardiopulmonary exercise performance testing to rule out an exercise-induced asthma by showing a decreased Tiffeneau index following intense physical activity. 22 Cardiopulmonary exercise performance testing The cardiopulmonary exercise performance was determined by cardiopulmonary exercise testing (CPET) with a bicycle ergometer (Excalibur Sport®, Lode B.V., Groningen, The Netherlands) and the spirometer in an upright position. Spiroergometry was performed with a gender-and age-adapted protocol using a stepwise load increase as previously published.…”

Section: Spirometrymentioning

confidence: 99%

Cardiorespiratory performance capacity and airway microbiome in patients following primary repair of esophageal atresia

et al. 2020

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BACKGROUND: Patients following repair of an esophageal atresia (EA) or tracheoesophageal fistula (TEF) carry an increased risk of long-term cardiopulmonary malaise. The role of the airway microbiome in EA/TEF patients remains unclear. METHODS: All EA/TEF patients treated between 1980 and 2010 were invited to a prospective clinical examination, spirometry, and spiroergometry. The airway microbiome was determined from deep induced sputum by 16 S rRNA gene sequencing. The results were compared to a healthy age-and sex-matched control group. RESULTS: Nineteen EA/TEF patients with a mean age of 24.7 ± 7 years and 19 age-and sex-matched controls were included. EA/TEF patients showed a significantly lower muscle mass, lower maximum vital capacity (VC max), and higher rates of restrictive ventilation disorders. Spiroergometry revealed a significantly lower relative performance capacity and lower peak VO 2 in EA/TEF patients. Alphaand beta-diversity of the airway microbiome did not differ significantly between the two groups. Linear discriminant effect size analysis revealed significantly enriched species of Prevotella_uncultured, Streptococcus_anginosus, Prevotella_7_Prevotella_enoeca, and Mogibacterium_timidum. CONCLUSION: EA/TEF patients frequently suffer from restrictive ventilation disorders and impaired cardiopulmonary function associated with minor alterations of the airway microbiome. Long-term examinations of EA/TEF patients seem to be necessary in order to detect impaired cardiopulmonary function.

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How to Diagnose Exercise Induced Asthma?

Cited by 9 publications

References 16 publications

Effects of continuous aerobic exercise on lung function and quality of life with asthma: a systematic review and meta-analysis

Effects of continuous aerobic exercise on lung function and quality of life with asthma: a systematic review and meta-analysis

Current Asthma Prevalence Using Methacholine Challenge Test in Korean Children from 2010 to 2014

Cardiorespiratory performance capacity and airway microbiome in patients following primary repair of esophageal atresia

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