How to estimate left ventricular hypertrophy in hypertensive patients

Lović, Dragan; Erdine, Serap; Çatakoğlu, Alp Burak

doi:10.5152/akd.2014.5115

Cited by 30 publications

(21 citation statements)

References 45 publications

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“…Echocardiographic diagnosis of LVH was made based on the left ventricular mass index (LVMI), which was calculated from measurements of interventricular septum thickness, posterior wall thickness of left ventricle, and end‐diastolic left ventricular diameter (Lovic et al. ).…”

Section: Methodsmentioning

confidence: 99%

Regular consumption of green tea improves pulse pressure and induces regression of left ventricular hypertrophy in hypertensive patients

Al-Shafei

El-Gendy

2019

Physiol Rep

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This study characterized the effects of regular green tea ( GT ) and hot water ( HW ) ingestion on systolic blood pressure ( SBP ), diastolic blood pressure ( DBP ), pulse pressure ( PP ), and left ventricular hypertrophy ( LVH ) in two equal, sex‐ and age‐matched groups; Grp1 and Grp2 ( n = 100 each; age 53 ± 4 years) of hypertensive patients. Grp1 had regular GT treatment, followed by HW ingestion, whereas Grp2 had HW ingestion followed by GT treatment for periods of 4 months each. Electrocardiographic ( ECG ) and echocardiographic assessments of LVH were made before and at the end of both periods. SBP was lowered significantly by 6.6%; DBP by 5.1%, and PP by 9.1% by the end of month 4 of GT treatment in Grp1. Upon GT cessation and HW ingestion, SBP , DBP , and PP returned to pretreatment levels over 4 months. In Grp2, SBP , DBP , and PP were reduced insignificantly by 1.5%, 1.0%, and 2.3% by the end of the 4th month of HW ingestion. Conversely, over 4 months of GT treatment, SBP , DBP , and PP were significantly lowered by 5.4%, 4.1%, and 7.7% from the baseline values, respectively. ECG and echocardiographic evidence of LVH was shown in 20% of Grp1 and 24% of Grp2 patients before intervention. This was significantly lowered to 8% and 10% in Grp1 and Grp2 by GT treatment. However, this increased to 16% following HW ingestion in Grp1. HW ingestion did mot induce regression of LVH in Grp2. Thus, regular GT ingestion has cardiovascular protective effects.

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Section: Methodsmentioning

confidence: 99%

Regular consumption of green tea improves pulse pressure and induces regression of left ventricular hypertrophy in hypertensive patients

Al-Shafei

El-Gendy

2019

Physiol Rep

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“…Left ventricular hypertrophy (LVH) is an important factor in the occurrence of cardiac remodeling and cardiovascular events [1]. Diabetes is a risk factor of LVH, which is independent of hypertension [2].…”

Section: Introductionmentioning

confidence: 99%

Association of Urine Albumin/Creatinine Ratio below 30 mg/g and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes

Xie

Peng

et al. 2020

BioMed Research International

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Several studies show that even a level of urine albumin/creatinine ratio (UACR) within the normal range (below 30 mg/g) increases the risk of cardiovascular diseases. We speculate that mildly increased UACR is related to left ventricular hypertrophy (LVH) in patients with type 2 diabetes mellitus (T2DM). In this retrospective study, 317 patients with diabetes with normal UACR, of whom 62 had LVH, were included. The associations between UACR and laboratory indicators, as well as LVH, were examined using multivariate linear regression and logistic regression, respectively. The diagnostic efficiency and the optimal cutoff point of UACR for LVH were evaluated using the area under the receiver operating characteristic curve (AUC) and Youden index. Our results showed that patients with LVH had significantly higher UACR than those without LVH (P<0.001). The prevalence of LVH presented an upward trend with the elevation of UACR. UACR was independently and positively associated with hemoglobin A1c (P<0.001). UACR can differentiate LVH (AUC = 0.682, 95% CI (0.602–0.760), P<0.001). The optimal cutoff point determined with the Youden index was UACR = 10.2 mg/g. When categorized by this cutoff point, the odds ratio (OR) for LVH in patients in the higher UACR group (10.2–30 mg/g) was 3.104 (95% CI: 1.557–6.188, P=0.001) compared with patients in the lower UACR group (<10.2 mg/g). When UACR was analyzed as a continuous variable, every double of increased UACR, the OR for LVH was 1.511 (95% CI: 1.047–2.180, P=0.028). Overall, UACR below 30 mg/g is associated with LVH in patients with T2DM. The optimal cutoff value of UACR for identifying LVH in diabetes is 10 mg/g.

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“…We found the incidence of coronary heart disease to be higher in the LVH(+) group, possibly because atherosclerosis patients are exposed to risk factors common to this condition and hypertensive LVH. Accumulating evidence has shown that LVH occurrence depends not only on hypertension duration and blood pressure levels, but also on other comorbidities, such as TG, age, gender, genetics, insulin resistance, obesity, physical inactivity, increased salt intake, and chronic stress, which play cooperative roles (Lovic et al, 2014). Besides these established risk factors, researchers have gradually begun to pay attention to the utility of certain inflammatory or oxidative mediators for early screening of populations at high risk of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Serum soluble RAGE level inversely correlates with left ventricular hypertrophy in essential hypertension patients

Q¹,

Hb²,

Luo³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Soluble receptor for advanced glycation end-products (sRAGE) acts as a decoy to prevent interaction between RAGE and its pro-inflammatory ligands. sRAGE levels have been found to decrease in chronic inflammatory diseases, including hypertension. However, few data have been reported concerning the association between serum sRAGE levels and hypertensive left ventricular hypertrophy (LVH). Fasting blood samples were obtained from 209 essential hypertensive patients, and sRAGE levels were measured using a commercially available double-sandwich enzyme-linked immunosorbent assay kit. All patients underwent complete transthoracic echocardiographic examination. LVH was defined as a left ventricular mass index >115 g/ m 2 for men and >95 g/m 2 for women. Eighty-one hypertensive patients (38.76%) were categorized in the LVH(+) group. Age (P = 0.009), hypertension duration (P = 0.013), triglyceride levels (P = 0.028), and systolic blood pressure (P = 0.026) were higher, and sRAGE and highdensity lipoprotein cholesterol levels were lower in the LVH(+) group compared with the LVH(-) group. Multivariate logistic regression analysis showed that sRAGE level [odds ratio (OR) = 0.916; 95% confidence interval (CI) = 0.864-0.984; P = 0.003], hypertension duration (OR = 1.024; 95%CI = 1.003-1.052; P = 0.027), and triglyceride level (OR = 1.017; 95%CI = 1.005-1.039; P = 0.018) were independent predictors of LVH in hypertensive patients. In conclusion, serum sRAGE level was inversely associated with LVH in hypertensive patients.

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How to estimate left ventricular hypertrophy in hypertensive patients

Cited by 30 publications

References 45 publications

Regular consumption of green tea improves pulse pressure and induces regression of left ventricular hypertrophy in hypertensive patients

Regular consumption of green tea improves pulse pressure and induces regression of left ventricular hypertrophy in hypertensive patients

Association of Urine Albumin/Creatinine Ratio below 30 mg/g and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes

Serum soluble RAGE level inversely correlates with left ventricular hypertrophy in essential hypertension patients

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