2024
DOI: 10.1002/cmdc.202400342
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How to Find a Fragment: Methods for Screening and Validation in Fragment‐Based Drug Discovery

Tim Kirkman,
Catharina dos Santos Silva,
Manuela Tosin
et al.

Abstract: Fragment‐based drug discovery (FBDD) is a crucial strategy for developing new drugs that have been applied to diverse targets, from neglected infectious diseases to cancer. With at least seven drugs already launched to the market, this approach has gained interest in both academics and industry in the last 20 years. FBDD relies on screening small libraries with about 1000‐2000 compounds of low molecular weight (about 300 Da) using several biophysical methods. Because of the reduced size of the compounds, the c… Show more

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