Advances in Experimental Medicine and Biology
DOI: 10.1007/0-387-25342-4_14
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How to Interpret a CSF—The Art and the Science

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Cited by 14 publications
(12 citation statements)
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References 140 publications
(138 reference statements)
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“…Most of CSF samples were obtained within 48 h of birth (to exclude early onset meningitis). We are aware of the maturational effect of post‐natal age on the normative values of WCC in the CSF of newborn infants, however, as most LPs were performed shortly after birth, we lacked the power to perform additional analysis by post‐natal age. As we did not obtain patient‐level clinical data, we could not determine the timing of the LP relative to commencing antibiotics.…”
Section: Discussionmentioning
confidence: 99%
“…Most of CSF samples were obtained within 48 h of birth (to exclude early onset meningitis). We are aware of the maturational effect of post‐natal age on the normative values of WCC in the CSF of newborn infants, however, as most LPs were performed shortly after birth, we lacked the power to perform additional analysis by post‐natal age. As we did not obtain patient‐level clinical data, we could not determine the timing of the LP relative to commencing antibiotics.…”
Section: Discussionmentioning
confidence: 99%
“…In blood-stained CSF samples, the WBC count was corrected according to the number of red blood cells using a fixed ratio of 1∶500 [24]. Definite meningitis was defined as the growth of a single bacterial pathogen from a CSF sample.…”
Section: Methodsmentioning
confidence: 99%
“…The definition of CSF pleocytosis was dependent on the infant's age. Our definition was based on published normal ranges for CSF white count in healthy infants 4,8,9 . For children ≤28 days old, we defined up to 20 WBC/mm 3 as normal.…”
Section: Methodsmentioning
confidence: 99%
“…Most of these studies did not exclude potentially treated meningitis because of prior antibiotics as the cause of sterile CSF pleocytosis. In addition, the individual studies from different institutions vary with their laboratory reference values for defining UTI and CSF pleocytosis from microbiology and biochemical tests 8 especially for neonates ≤28 days of age 9 . The mechanism of CSF pleocytosis in UTI is unknown, although it is hypothesised that bacterial antigens can interact with CD14 and toll‐like receptor 4 in the brain, resulting in an inflammatory response 10 …”
mentioning
confidence: 99%