How to Interpret Findings Concerning Newly Approved Antipsychotic Agents

Correll, Christoph U.; Malla, Ashok; Meyer, Jonathan M.

doi:10.4088/jcp.11078ip1

Cited by 1 publication

(1 citation statement)

References 48 publications

(57 reference statements)

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“…Stimulants used in the treatment of ADHD are thought to act by increasing brain catecholamine levels ( 56 ) and are effective in 65–75% of children after a first stimulant trial ( 57 ). Methylphenidate blocks dopamine and norepinephrine re-uptake transporters ( 58 ) and has been used for the treatment of ADHD for many decades.…”

Section: Controversies Surrounding the Treatment Of Adhdmentioning

confidence: 99%

Why the Diagnosis of Attention Deficit Hyperactivity Disorder Matters

2015

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BackgroundAttention Deficit Hyperactivity disorder (ADHD) is one of the most common and challenging childhood neurobehavioral disorders. ADHD is known to negatively impact children, their families, and their community. About one-third to one-half of patients with ADHD will have persistent symptoms into adulthood. The prevalence in the United States is estimated at 5–11%, representing 6.4 million children nationwide. The variability in the prevalence of ADHD worldwide and within the US may be due to the wide range of factors that affect accurate assessment of children and youth. Because of these obstacles to assessment, ADHD is under-diagnosed, misdiagnosed, and undertreated.ObjectivesWe examined factors associated with making and receiving the diagnosis of ADHD. We sought to review the consequences of a lack of diagnosis and treatment for ADHD on children’s and adolescent’s lives and how their families and the community may be involved in these consequences.MethodsWe reviewed scientific articles looking for factors that impact the identification and diagnosis of ADHD and articles that demonstrate naturalistic outcomes of diagnosis and treatment. The data bases PubMed and Google scholar were searched from the year 1995 to 2015 using the search terms “ADHD, diagnosis, outcomes.” We then reviewed abstracts and reference lists within those articles to rule out or rule in these or other articles.ResultsMultiple factors have significant impact in the identification and diagnosis of ADHD including parents, healthcare providers, teachers, and aspects of the environment. Only a few studies detailed the impact of not diagnosing ADHD, with unclear consequences independent of treatment. A more significant number of studies have examined the impact of untreated ADHD. The experience around receiving a diagnosis described by individuals with ADHD provides some additional insights.ConclusionADHD diagnosis is influenced by perceptions of many different members of a child’s community. A lack of clear understanding of ADHD and the importance of its diagnosis and treatment still exists among many members of the community including parents, teachers, and healthcare providers. More basic and clinical research will improve methods of diagnosis and information dissemination. Even before further advancements in science, strong partnerships between clinicians and patients with ADHD may be the best way to reduce the negative impacts of this disorder.

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Section: Controversies Surrounding the Treatment Of Adhdmentioning

confidence: 99%