This paper presents an enhanced version of the AED (Appropriate Executive Decisions) algorithm, which is based on biological immune system (BIS) and whose purpose is the generation of appropriate executive decisions aimed at business environments. A new metric has been incorporated to the algorithm and a larger and more representative database was used to train and validate results. Moreover, this paper offers better directions on how to apply AED in executive decisions, affording the learning process quality improvement through immunoinformatics concepts, namely decision cells, thereby producing more appropriate executive decisions. Experiments were carried out with executive officers experienced in executive decisions in order to suitably validate the appropriateness of responses generated by the enhanced AED algorithm.