How to prevent medication errors: a multidimensional scaling study to investigate the distinguishability between self-injection platform device variants

Schneider, Andréas; Kolrep, Harald; Jordi, Christoph; Richard, Philipp; Horn, Hanns-Peter; Lange, Jakob

doi:10.1080/17425247.2019.1637852

Cited by 7 publications

(10 citation statements)

References 58 publications

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“…Each participant sequentially simulated three injections using a standard handheld disposable autoinjector (YpsoMate®, Ypsomed AG, Burgdorf, Switzerland) described earlier [e.g. 26,28,44]. The selected autoinjector is well suited for studying the impact of injection duration on user's force, as its push-onskin handling concept has been demonstrated to support safe and effective drug self-administration across user groups and disease states [e.g.…”

Section: Methodsmentioning

confidence: 99%

“…Thirty-two subjects from the Philadelphia Greater Metropolitan Area, PA, USA, were recruited for this study. Patients (groups G1-G3, n = 19), nonprofessional caregivers (group G4, n = 6) and health-care professionals (group G5, n = 7) were included to reflect the intended usage population of single-use autoinjectors [4,28,43]. From the 24 female and 8 male participants, 20 had injection experience and the remaining 12 did not have experience.…”

Section: Samplementioning

confidence: 99%

“…25] for use with equally novel and easy-to -use handheld autoinjectors [e.g. 4,5,[26][27][28], foster highvolume drug administration. As a consequence, emerging dosing regimens demand the administration of a single bolus dose up to 2 mL [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Hold the device against the skin: the impact of injection duration on user’s force for handheld autoinjectors

Schneider

Mueller

Jordi

et al. 2019

Expert Opinion on Drug Delivery

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Background: The recent development of high-volume subcutaneous drug delivery using handheld autoinjectors has resulted in longer injection durations. However, the usability of long injections has been neglected. This study aimed to investigate the effects of injection duration on users' ability to apply injections while holding the device against the skin at the injection site. Methods: Thirty-two participants among patients, caregivers, and health-care professionals simulated three injections with different injection durations to evaluate usability and user's force. Linear and quantile regression were then applied to determine the impact of the injection duration on response variables related to user's force. Results: A significant negative effect of injection time was found on both the minimum and mean user's force applied. Initial empirical evidence was also determined on the negative association being more pronounced for users exerting lower force to hold the device against the skin. Conclusions:The results that are subject to future clinical validation suggest the feasibility of injections lasting up to approximately 30 s using handheld autoinjectors. The participants of the simulated use study successfully applied long-duration injections regardless of disease states, age, or visual and dexterity impairments. ARTICLE HISTORY

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Section: Methodsmentioning

confidence: 99%

Section: Samplementioning

confidence: 99%

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Hold the device against the skin: the impact of injection duration on user’s force for handheld autoinjectors

Schneider

Mueller

Jordi

et al. 2019

Expert Opinion on Drug Delivery

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“…Participants across five user groups (G1 -G5, N = 42) were included to account for the broad user population of the autoinjector platform at hand. 1,2,39 Patient users were placed in one of three age groups (adolescent patients, G1, n = 6; adult patients, G2, n = 11; elder patients, G3, n = 12) to assess the influence of decreasing dexterity on the ability to effectively remove the autoinjector cap. This study refers to dexterity impairment as the extent to which chronic submit your manuscript | www.dovepress.com…”

Section: Participantsmentioning

confidence: 99%

“…Soaring interest in biologics and their subcutaneous delivery has accelerated the market uptake of pre-filled autoinjectors for the automated self-administration of single fixed doses across chronic disease states. 1,2 While such autoinjectors typically maintain the pharmacokinetics, efficacy, and safety profiles of manual injections, 3,4 they offer distinct advantages over syringes that shape patient preference and adherence. First, pre-filled autoinjectors are preferred over syringes in head-to-head comparison studies, thus influencing overall treatment choices.…”

Section: Introductionmentioning

confidence: 99%

User-Centric Approach to Specifying Technical Attributes of Drug Delivery Devices: Empirical Study of Autoinjector-Cap Removal Forces

Schneider¹,

Richard²,

Mueller³

et al. 2021

PPA

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Purpose The subcutaneous delivery of biologics using pre-filled autoinjector devices continues to attract broad scholarly interests. However, research still lacks a detailed understanding of user perceptions as the basis for specifying the clinically relevant technical attributes of a device, such as the cap-removal force. Therefore, this article studies the ability of users to remove the autoinjector cap, as well as the effects of the cap-removal force and user characteristics on the perceived ease of decapping. Patients and Methods Forty-two participants among patients, caregivers, and healthcare professionals removed the protective cap using non-functional devices with different target cap-removal forces between 25 N and 55 N. Data were collected on the ability of the users to effectively decap the device and their perceived ease of decapping. Linear regression was then applied to quantify the impact of the decapping force and patient characteristics on the perceived ease of decapping. Results The participants of the study effectively decapped all autoinjector devices irrespective of age, sex, and dexterity impairments. Moreover, the study reveals that the perceived ease of decapping decreases significantly with increasing decapping force and participants’ dexterity impairments. Conclusion The study provides initial empirical evidence on the ability of users to decap autoinjector devices and shows how increasing the cap-removal force and dexterity impairments reduce the perceived ease of decapping.

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The current paradigm for biologic initiation: a mixed-methods exploration of practices, unmet needs, and innovation opportunities in self-injection training

Rinaldi¹,

Katsaros

Hawthorne

et al. 2021

Expert Opinion on Drug Delivery

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How to prevent medication errors: a multidimensional scaling study to investigate the distinguishability between self-injection platform device variants

Abstract: Lange (2019) How to prevent medication errors: a multidimensional scaling study to investigate the distinguishability between self-injection platform device variants, Expert

Cited by 7 publications

References 58 publications

Hold the device against the skin: the impact of injection duration on user’s force for handheld autoinjectors

Hold the device against the skin: the impact of injection duration on user’s force for handheld autoinjectors

User-Centric Approach to Specifying Technical Attributes of Drug Delivery Devices: Empirical Study of Autoinjector-Cap Removal Forces

The current paradigm for biologic initiation: a mixed-methods exploration of practices, unmet needs, and innovation opportunities in self-injection training

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