Commentary on Scheidell et al. (2018): En-counting adversities; the 'building blocks' of psychopathology Exposure to traumatic stressors, especially early in life, are the 'building blocks' for psychopathology and substance misuse, with consequences extending beyond the individual, to the family, society and the next generation.The greater the cumulative exposure to traumatic stressors, the greater the damage to health and psychological functioning. Although the amount of harm inflicted within any particular 'trauma' varies from person to person, it is possible to measure this statistically. Numerous studies have shown that the degree of harm caused by individual 'wounds', i.e. the trauma, depends upon several factors. These include the type, proximity and frequency of traumata and previous experiences as well as the genetics, epigenetics, resilience, gender, age or cognitive capacity of the individual who encounters trauma [1][2][3][4][5].Given this variation, it is surprising that merely counting traumatic exposures can predict detrimental consequences for psychological functioning. This was, however, shown in the seminal Adverse Childhood Experiences (ACE) studies, and now Scheidell and colleagues demonstrate that it also occurs for substance use and abuse [6]. Although an event's exact 'dose' of trauma (how much of the active substance, i.e. the 'traumatic stressors') is unknown, and its frequency (how often it occurs within a given time-span) is typically variable, there is undoubtedly a simple occurrence-dependent association between trauma and its consequences: the earlier in life, and the more often, the worse the impact. Like building blocks, each traumatic stressor adds to symptom severity and chronicity [7,8] not only for post-traumatic stress disorder (PTSD), but also for other areas of social and occupational functioning such as depressive symptoms, somatic problems and immunological changes [9][10][11][12]. The particularly 'toxic' stressors are those which involve serious threats to physical integrity (damage to the central nervous system, body and organs), threats to social integrity (social exclusion, loss of status) and threats to genetic fitness (rape, danger to the gene pool, long-standing cooperation and aggressive dominance behaviours).Traumatic stressors have particularly strong effects on the minds and bodies of children and adolescents, as the pathways of inflammation and stress hormones influence development of the child's brain directly [4,5]. Cumulative trauma during childhood predicts internalized and externalized destructive behaviours among young people and exacerbates later mental illness. The consequences are dramatic, and extend far beyond specific traumatic disturbances such as PTSD or disturbances of the affective spectrum. The behavioural consequences can include aggression and the perpetration of violence [13,14]. Scheidell and colleagues have demonstrated that traumatic stressors also cause destruction via substance misuse, associated with violence, reactive and appetitive ...