How to Simplify the Diagnostic Criteria of Metabolic Syndrome in Adolescents

Ma, Chunxiao; Yin, Fei; Liu, Xiaoli; Wang, Rui; Lou, Dong-Hui; Lu, Qiang

doi:10.1016/j.pedneo.2016.03.008

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…According to traditional definition, adolescents were classified as having MetS if they had 3 or more of the following criteria 12 : (1) abdominal obesity: WC ≥90th percentile (age-specific and sex-specific) 13 ; (2) elevated BP: SBP or DBP ≥90th percentile (age-specific, sex-specific, and height-specific) 14 ; (3) hypertriglyceridemia: TG concentration ≥1.24 mmol/L; (4) low HDL-C: HDL-C concentration ≤1.03mmol/L; and (5) elevated blood glucose: fasting glucose concentration ≥5.6mmol/L. According to height-corrected MetS definition, adolescents were classified as having MetS if they had 3 or more of the following criteria 11 : (1) abdominal obesity: WHtR ≥0.5; 15 (2) elevated BP: SBPHR/DBPHR ≥0.68/0.43 for boys and ≥0.72/0.45 for girls 16 ; (3) hypertriglyceridemia: TG concentration ≥1.24mmol/L; (4) low HDL-C: HDL-C concentration ≤1.03mmol/L; and (5) elevated blood glucose: fasting glucose concentration ≥5.6 mmol/L.…”

Section: Methodsmentioning

confidence: 99%

“…[7][8][9][10] In a previous study, we proposed the height-corrected definition of MetS. 11 In this method, WHtR and BPHR were substituted for WC and BP when defining MetS in adolescents (Table 1). As a result of simple calculations, the definition of MetS was simplified to non-age and height-dependent cutoff points that are easy for professionals and laypeople to manipulate.…”

Section: Introductionmentioning

confidence: 99%

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Height-Corrected Definition of Metabolic Syndrome Is a Simple and Effective Method for Identifying Insulin Resistance and Low-Grade Inflammation in Adolescents: Metabolic Syndrome in Adolescents

Liu

Lü

et al. 2023

Clin Pediatr (Phila)

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The purpose of this study was to evaluate the feasibility of the height-corrected definition of metabolic syndrome(MetS) in adolescents. A retrospective study was conducted on US adolescents aged 12 to 17 years. Waist-to-height ratio and blood pressure-to-height ratio were substituted for waist circumference and blood pressure when defining MetS in adolescents. The proportions of insulin resistance of adolescents with 1 (30.1%), 2 (50.7%), and ≥3 components (77.8%) of MetS were 2.578 ( P < .001), 6.882 ( P < .001), and 23.992 ( P < .001) times than the proportion of adolescents without the component of MetS (14.2%). The proportions of low-grade inflammation of adolescents with 1 (3.4%), 2 (5.3%), and ≥3 components (14.4%) of MetS were 2.050 ( P = .106), 3.699 ( P = .005), and 10.664 ( P < .001) times than the proportion of adolescents without the component of MetS (1.7%). This study demonstrates that height-corrected definition of MetS is a simple and accurate method for identifying insulin resistance and low-grade inflammation in adolescents.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Height-Corrected Definition of Metabolic Syndrome Is a Simple and Effective Method for Identifying Insulin Resistance and Low-Grade Inflammation in Adolescents: Metabolic Syndrome in Adolescents

Liu

Lü

et al. 2023

Clin Pediatr (Phila)

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“…University Hospital of Chuzhou University (Chuzhou, China) were selected. All patients were diagnosed according to the criteria established by a previous study (11). Patients who met three of the following four criteria were diagnosed with metabolic syndrome: i) Overweight and/or obese, with a body mass index of ≥25; ii) had a fasting plasma glucose of ≥6.1 mmol/l (110 mg/dl) and/or 2-h plasma glucose of ≥7.8 mmol/l (140 mg/dl), and/or had been diagnosed with diabetes and treated; iii) had systolic/diastolic blood pressure of ≥140/90 mmHg, and/or had been diagnosed with hypertension and treated; and iv) had a fasting triglyceride level of ≥1.7 mmol/l (150 mg/dl), and/or a high-density lipoprotein cholesterol level of <0.9 mmol/l (35 mg/dl) for males and <1.0 mmol/l (39 mg/dl) for females.…”

Section: Swimming Intervention Alleviates Insulin Resistance and Chromentioning

confidence: 99%

Swimming intervention alleviates insulin resistance and chronic inflammation in metabolic syndrome

Tan

Guo

2018

Exp Ther Med

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In view of the high incidence of metabolic syndrome and the role of exercise in promoting metabolic disorders, the present study aimed to investigate the therapeutic effects of swimming intervention on metabolic syndrome. In the present study, a total of 100 patients with metabolic syndrome and 100 healthy individuals were included. Fasting blood was extracted from each participant, and the serum levels of interleukin (IL)-1, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor α (TNF-α) and IL-8 were measured by sandwich enzyme-linked immunosorbent assay. Patients were randomly divided into five groups (groups A-E). Patients in group A was treated with conventional drug treatment. Besides conventional treatment, patients in groups BE were also subjected to swimming intervention for 15, 30, 45 and 60 min each time, respectively, four times a week for 3 months. Changes in the homeostatic model assessment of β-cell function and insulin resistance (HOMA-IR) score, and in the serum levels of IL-1, hs-CRP, TNF-α and IL-8 were recorded. Furthermore, muscle tissues were collected from patients, and the expression levels of insulin receptor substrate-1 (IRS-1), glucose transporter type 4 (GLUT4) and protein kinase B (Akt) in the tissues were detected by western blot assay. The results revealed that HOMA-IR and the serum levels of IL-1, hs-CRP, TNF-α and IL-8 were significantly higher in metabolic syndrome patients as compared with those in the normal controls, while swimming intervention reduced HOMA-IR and these serum levels to different extents. Swimming intervention also promoted IRS-1 and Akt phosphorylation, and increased GLUT4 expression level. Thus, it is concluded that swimming intervention may improve metabolic syndrome through multiple pathways.

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“…3 Given that blood tests screening CMR in asymptomatic children is unacceptable in routine health examinations, anthropometric indexes with good correlation with CMR in children population has the potential to be used for screening in practice. [4][5][6][7] Previous work has demonstrated the promise of waist-to-height ratio (WHtR), an obesity-related anthropometric index, as an efficient tool for quick and mass screening of CMR in children. [8][9][10][11][12][13] However, given the strengths and limitations of this study ► As the largest nationwide cross-sectional study in the paediatric population, our findings enhanced the generalisability of waist-to-height ratio (WHtR) to practice.…”

Section: Introductionmentioning

confidence: 99%

Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China

et al. 2020

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ObjectivesTo demonstrate the accuracy and flexibility of using waist-to-height ratio (WHtR) as a screening tool for identifying children and adolescents with cardiometabolic risk (CMR) across a wide range of prevalence levels among general paediatric populations.DesignA nationwide population-based cross-sectional study with all data collected at school settings in six cities of China.ParticipantsA total of 8130 children and adolescents aged 7–18 years with complete anthropometric and CMR measurements based on blood tests were recruited.Outcome measuresElevated blood pressure, dyslipidaemia, elevated fasting blood glucose and central obesity were measured. The primary outcome, CMRs, was defined as meeting three or more of the above risk factors. The accuracy of WHtR for identifying CMRs was evaluated using areas under the curves (AUCs) with 95% CI of the receiver operating characteristic curve. The predictability of WHtR at given CMRs prevalence levels was estimated by positive predictive value (PPV) and negative predictive value.ResultsOverall, 6.1% of study participants were presented with CMRs. WHtR had high AUCs ranging from 0.84 (95% CI 0.81 to 0.88) to 0.88 (95% CI 0.86 to 0.90) in the total population and age-subgroup and gender-subgroup. The overall optimal WHtR cut-off value was 0.467, with boys having a higher cut-off than girls (0.481 vs 0.456). WHtR achieved an overall sensitivity of 0.89 and PPV of 18.8% at a specificity of 0.75. The screening performance of WHtR remained satisfactory across a wide range of given CMRs prevalence levels (5%, 10% and 20%).ConclusionWHtR as a screening tool could accurately and flexibly identify children affected with the clusters of three or more of CMR factors from the general paediatric population with various CMR prevalence levels. Our findings provide support for policy-making on early CMR identification and management in the high-risk group of children.

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How to Simplify the Diagnostic Criteria of Metabolic Syndrome in Adolescents

Abstract: The present study demonstrates that the height-corrected definition of MS is a simple, inexpensive, and accurate tool for identifying MS in Han adolescents.

Cited by 8 publications

References 35 publications

Height-Corrected Definition of Metabolic Syndrome Is a Simple and Effective Method for Identifying Insulin Resistance and Low-Grade Inflammation in Adolescents: Metabolic Syndrome in Adolescents

Height-Corrected Definition of Metabolic Syndrome Is a Simple and Effective Method for Identifying Insulin Resistance and Low-Grade Inflammation in Adolescents: Metabolic Syndrome in Adolescents

Swimming intervention alleviates insulin resistance and chronic inflammation in metabolic syndrome

Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China

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