How to use C-reactive protein

Dyer, Emma M; Waterfield, Thomas; Baynes, Hannah

doi:10.1136/archdischild-2018-315079

Cited by 19 publications

(10 citation statements)

References 15 publications

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“…In this study, CRP levels were detected in 80 patients with cervical cancer after general anesthesia. After 24 h, CRP levels were abnormally increased in patients with pulmonary infection which is consistent with the results of previous studies (17), and suggests that CRP was involved in the occurrence of the disease. One possible explanation is that the massive production and aggregation of CRP and other cytokines can cause neuronal cell damage and apoptosis of astrocytes, inducing a cascade reaction of cytokines which can promote the occurrence of pulmonary inflammation (18).…”

Section: Discussionsupporting

confidence: 91%

The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment

Liu¹,

Tian²,

You³

et al. 2021

Ann Palliat Med

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Background: To analyze the predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT), and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment. Methods:We enrolled 80 patients who underwent radical surgery for cervical cancer in our hospital from March 2018 to March 2020 and divided them into an infected group (n=34) and non-infected group (n=46) according to whether they were complicated by lung infection after surgery. The levels of CRP, PCT, and TREM-1 were compared between the two groups, and logistic regression was used to analyze the risk factors for pulmonary infection. The ROC curve was used to analyze the predictive value of the individual detection of CRP, PCT, or TREM-1 as well as their combined detection. Results:The levels of CRP, PCT, and TREM-1 in the infected group were higher than those in non-the infected group 24 h after operation (P<0.05) and tumor TNM staging, previous lung disease, postoperative use of a ventilator, intraoperative use of antibacterial drugs, PCT, CRP, and ICAM-1 were significantly correlated with pulmonary infection (P<0.05). The postoperative application of a ventilator, PCT (increasing), CRP (increasing), and ICAM-1 (increasing) were all individual factors that could affect the development of pulmonary infection (P<0.05). ROC curve results showed that the critical score of combined detection was 3.026, and the area under the curve (AUC) was 0.786 (0.637-0.935), the sensitivity was 90.52%, and the specificity was 89.63%. Conclusions:The levels of PCT, CRP, and TREM-1 are abnormally increased in patients with pulmonary infection after laparoscopic general anesthesia for cervical cancer treatment. Their combined detection can be used as an effective means to predict the occurrence of pulmonary infections in the early stage and their level should direct timely intervention to improve the prognosis of patients.

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Section: Discussionsupporting

confidence: 91%

The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment

Liu¹,

Tian²,

You³

et al. 2021

Ann Palliat Med

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“…Once the inflammation subsided, CRP would rapidly decrease. At present, CRP is recognised as an effective and intuitive response to the body's sensitive biological indicators, widely used in clinical diagnosis [ 15 , 16 ]. In this study, CRP levels in children with bacterial respiratory tract infection were significantly higher than those in children with non-bacterial respiratory tract infection and healthy children; after conventional antibiotic therapy, CRP levels were significantly reduced to normal levels, indicating that the detection of CRP levels has a guiding role in clinical medication.…”

Section: Discussionmentioning

confidence: 99%

Value of combined detection of serum amyloid A, C-reactive protein and procalcitonin in differential diagnosis of respiratory tract infection in children of China

Yin

2022

Annals of Medicine

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Objective To explore the diagnostic value of combined detection of serum amyloid A (SAA), C-reactive protein (CRP) and procalcitonin (PCT) in children with bacteria or non-bacterial respiratory tract infection. Methods 200 children with respiratory tract infections diagnosed in our hospital were included in the study. According to the results of the aetiological examination, they were divided into bacterial infection group and non-bacterial infection group. At the same time, 100 healthy children admitted to the hospital for physical examination during the same period were selected as the healthy subjects control group. Changes in serum SAA, PCT and CRP in three groups were compared. Comparison of a positive rate of the single index and combined detection were performed. Children with bacterial infections were treated with conventional antibiotics. The changes in serum SAA, PCT and CRP in the infection group before and after treatment were compared. The efficacy of SAA, PCT and CRP alone and in combination was compared. Results The serum SAA, PCT and CRP levels in the bacterial infection group were higher than those in the non-bacterial infection group and healthy children, and the differences were statistically significant. The positive detection rates and combined detection rates of serum SAA, PCT and CRP in the bacterial infection group were higher than those in the non-bacterial infection group and the healthy subject's control group. After conventional antibiotic treatment, serum SAA, PCT and CR levels in children with bacterial infection were significantly decreased. Conclusion The combined detection based on SAA, CRP and PCT can effectively identify and diagnose respiratory tract infection in children, providing a certain reference for the promotion of the diagnostic scheme. Key messages Serum SAA, PCT and CRP were highly expressed in children with respiratory tract infection, and the expression level was the highest in children with bacterial pneumonia. The combined detection of serum SAA, CRP and PCT indicators have higher diagnostic efficiency and can effectively make a differential diagnosis of respiratory tract infection in children.

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“…Furthermore, the biological plausibility of CRP rising within 4 hours after starting HD is questionable. CRP typically starts increasing 4–6 hours after the onset of inflammation and peaks 36–50 hours later [ 31 ]. Therefore, this may explain the absence of any difference before and after dialysis.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Hemodialysis Session on Markers of Inflammation and Endotoxin

Dheda

Vesey

Hawley

et al. 2022

International Journal of Inflammation

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Background. People receiving hemodialysis (HD) treatment have higher cardiovascular morbidity and mortality, ascribed to an increased prevalence of traditional cardiovascular risk factors. However, the role of nontraditional risk factors, such as inflammation, has become increasingly recognized. The origin of this inflammation remains elusive and one putative cause is elevated levels of circulating bacterial endotoxin. Methods. In this study, serum concentrations of endotoxin and inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), interleukin-1β (IL1β), ferritin and tumor necrosis factor (TNF), were measured in 30 adults receiving HD and 10 healthy individuals without kidney disease. In people receiving HD, samples were collected immediately before dialysis (preHD), after dialysis (postHD), and 48 hours after (postHD48hrs). Results. Endotoxin was detectable in only 1 of 90 samples analyzed. There were no significant differences in serum hsCRP, IL1β, and IL6 levels, before and after dialysis. Serum TNF levels decreased significantly from 30.9 (8.0, 39.5) pg/mL preHD to 13.9 (8.5, 17.3) pg/mL post-HD ( p = 0.002 ) and then increased back to 27.37 (14.5, 35) pg/mL 2 days later ( p < 0.001 ). Ferritin increased from 1153 ng/mL (782, 1458) preHD to 1313 ng/mL (657, 1638) post HD ( p < 0.001 ) and then decreased back to 1186 ng/mL (754, 1597) ( p = 0.66 ) postHD48hrs. Compared to controls, people receiving HD had significantly elevated levels of hsCRP [6.16 mg/L (2.1, 16.8) vs. 1.1 mg/L (0.81, 3.63) p = 0.015 ], IL1β [1.5 pg/mL (0.05, 2.51) vs. 0.5 pg/mL (1.81, 2.95) p ≤ 0.001 ], and ferritin [1153 (782, 1458) vs. 132.9 (111, 257) ng/mL p ≤ 0.001 ], but comparable levels of in IL6 [6.15 pg/mL (4.82, 9.12) vs. 7.49 pg/mL (4.56, 10.39), p = 0.77 ] and TNF [27.35 pg/mL ± 17.48 vs. 17.87 pg/mL ± 12.28, p < 0.12 ]. In conclusion, people on HD have elevated levels of inflammatory biomarkers, which are not associated with endotoxemia (which is rare) or the dialysis procedure.

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How to use C-reactive protein

Cited by 19 publications

References 15 publications

The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment

The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment

Value of combined detection of serum amyloid A, C-reactive protein and procalcitonin in differential diagnosis of respiratory tract infection in children of China

Effect of a Hemodialysis Session on Markers of Inflammation and Endotoxin

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