How useful are anti-neural IgM antibodies in the diagnosis of chronic immune-mediated neuropathies?

Nobile‐Orazio, Eduardo; Gallia, Francesca; Terenghi, F.; Allaria, S.; Giannotta, Claudia; Carpo, M.

doi:10.1016/j.jns.2007.09.020

Cited by 76 publications

(68 citation statements)

References 45 publications

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“…7 In a recent study of 539 patients at a neuropathy clinic in Italy, GM1 antibodies were found relatively frequently in patients with MMN (n ¼ 12), neuropathy with elevated M protein (n ¼ 10), chronic inflammatory demyelinating polyneuropathy [CIDP (n ¼ 6)], and motor neuron disease (n ¼ 6). 11 Less frequently (n < 4 for each diagnosis) anti-GM1 antibodies were found in patients diagnosed with IgG monoclonal gammopathy, POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes), mononeuritis multiplex, radiculopathy or plexopathy, and undiagnosed neuropathy. Anti-GM1 antibody has also been reported in normal controls 12 and other conditions such as paraneoplastic 13 and connective tissue disease.…”

Section: Discussionmentioning

confidence: 99%

Demyelinating symmetric motor polyneuropathy with high titers of anti‐GM1 antibodies

2010

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High titers of anti-GM1 ganglioside antibodies have been associated with multifocal motor neuropathy, a chronic asymmetric and exclusively motor disorder. We describe a patient with a progressive selective motor but symmetric polyneuropathy, followed over 5 years, with markedly elevated titers of anti-GM1 antibodies. The electrophysiological changes suggestive of motor demyelination were widespread, beyond conduction block alone, and involved contiguous nerve segments with complete sparing of sensory conduction. Progressive, predominantly motor, symmetric, demyelinating polyneuropathy may be an unusual relative of multifocal motor neuropathy, associated with anti-GM1 antibodies.

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Section: Discussionmentioning

confidence: 99%

Demyelinating symmetric motor polyneuropathy with high titers of anti‐GM1 antibodies

2010

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“…Patients' sera were tested by Enzyme Linked Immunosorbent Assay (ELISA) for IgM reactivity to the individual gangliosides GM1, GM2, GD1a, GD1b and GT1b (0.5 μg/well for of each ganglioside) as previously reported (Nobile-Orazio et al, 2008). To better correlate the results obtained with ganglioside complexes, we slightly modified the procedure by testing patients' sera at the dilution of 1:200 and by considering positive the sera when the difference in the absorbance between wells coated with the ganglioside and bovine serum albumin (BSA) exceed 0.100.…”

Section: Methodsmentioning

confidence: 99%

“…The pathogenic role of these antibodies in MMN is still unclear as well as what causes the disease in MMN GM1 negative patients. It is also unclear how similar antibodies may be associated with and potentially responsible for different diseases (Nobile-Orazio, 2001). Recently, several reports described the presence of IgG antibodies against complexes of different gangliosides, called anti-ganglioside complexes (GSCs) antibodies, in patients with Guillain-Barré or Fisher syndrome (Kaida et al, 2004(Kaida et al, , 2006.…”

Section: Introductionmentioning

confidence: 99%

Anti-ganglioside complex IgM antibodies in multifocal motor neuropathy and chronic immune-mediated neuropathies

Nobile‐Orazio¹,

Giannotta²,

Briani³

2010

Journal of Neuroimmunology

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“…All these cases had IgM MGUS. The specificity and positive predictive value for neuropathy of anti-MAG antibodies among patients with IgM MGUS were 93.2 % and 91.4 %, respectively [29].…”

Section: Discussionmentioning

confidence: 92%

IgM MGUS associated with anti-MAG neuropathy: a single institution experience

et al. 2015

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Anti-MAG neuropathy is a very rare form of acquired polyneuropathy associated with IgM monoclonal gammopathy of undetermined significance (MGUS). We conducted a retrospective review of 194 consecutive MGUS patients seen at the Penn State Hershey Cancer Institute. We identified six patients among 37 (16 %) with IgM MGUS with anti-MAG neuropathy. Interestingly, an additional patient had anti-MAG neuropathy without MGUS. Common clinical manifestations were numbness and paresthesias of the extremities and gait imbalance. All four patients treated with rituximab and none of the three untreated ones had a subjective improvement of their symptoms. We conclude that all patients with IgM MGUS and neuropathy should be screened for anti-MAG antibodies and, if positive, they should be offered treatment with rituximab.

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How useful are anti-neural IgM antibodies in the diagnosis of chronic immune-mediated neuropathies?

Cited by 76 publications

References 45 publications

Demyelinating symmetric motor polyneuropathy with high titers of anti‐GM1 antibodies

Demyelinating symmetric motor polyneuropathy with high titers of anti‐GM1 antibodies

Anti-ganglioside complex IgM antibodies in multifocal motor neuropathy and chronic immune-mediated neuropathies

IgM MGUS associated with anti-MAG neuropathy: a single institution experience

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