How We See Others:<i>The Psychobiology of Schemas and Transference</i>

Stein, Dan J.

doi:10.1017/s1092852900020009

Cited by 18 publications

(2 citation statements)

References 42 publications

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“…actions are likely to be relevant to emotional dysregulation and impulse dyscontrol, as well as to attachment disruption and schema distortion. 16 -5861 Preliminary studies are consistent with involvement of monoaminergic genes in Bpp 2i ,6264 Monoaminergic variants have a functional impact on circuitry involved in mediating emotional regulation and impulse control, 65 and this may also be apparent in BPD. 66…”

Section: Pearls In Clinical Neurosciencementioning

confidence: 89%

Borderline Personality Disorder:Toward Integration

Stein¹

2009

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Several psychiatric disorders, including borderline personality disorder (BPD), are characterized by emotional dysregulation and impulse dyscontrol. More specifically, symptoms in patients with BPD often occur within the context of disruptions in attachment and related distortions in cognitive-affective processing of the self and others. From a neurocircuitry perspective, findings include prefrontal hypoactivity, amygdala hyperreactivity, and alterations in prefrontal-limbic interaction. Molecular pathways relevant to these circuits include the serotonergic, noradrenergic, and dopaminergic systems, and there is some evidence that pharmacotherapy with agents that act on these systems may be useful. Given the disruptions in attachment and schemas of the self and others in BPD, establishing a therapeutic alliance is crucial while psychotherapy remains the cornerstone of an integrated approach to management.

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Section: Pearls In Clinical Neurosciencementioning

confidence: 89%

Borderline Personality Disorder:Toward Integration

Stein¹

2009

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“…Assessment of social attachment and affiliation is an important component of the psychiatric evaluation, and is also a key part of the ongoing evaluation of the doctor-patient relationship. 49…”

Section: Assessment/evaluationmentioning

confidence: 99%

Oxytocin and Vasopressin: Social Neuropeptides

Stein¹

2009

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Oxytocin and vasopressin are highly conserved neuropeptides that play a key role in social attachment and affiliation, including parental care and pair-bonding. Oxytocin attenuates neural responses to aversive pictures and has been associated with reduced coupling of amygdala to brainstem regions involved in the fear response. Differential activation of the amygdala has been found to be associated with different genetic variants of the vasopressin receptor. There is growing evidence that oxytocin and vasopressin receptor variants are associated with individual differences in prosocial behavior. It is humbling that differences in complex human behaviors may be partially explicable on the basis of relatively simple neuropeptide systems. Nevertheless, such findings potentially allow for targeted interventions for a range of psychiatric disorders in which such systems play a role.

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