This chapter delves into the comprehensive examination of upskilling and motivating a multigenerational workforce in the post-pandemic era, marked by remote work and increased technology adoption. It underscores the importance of comprehending the unique values and work habits exhibited by diverse generational cohorts, presenting a comparative analysis of each generation's characteristics. The chapter also delves into the far-reaching effects of the pandemic on remote work and emphasizes the necessity for customized training programs to cater to different segments of the workforce. Furthermore, it explores the integration of technology in human resource management (HRM) and delves into the ethical implications arising from AI and machine learning. Lastly, the chapter underscores the significance of managing employee well-being, particularly within the pandemic context, and proposes strategies to foster physical and psychological health. Ultimately, the chapter establishes a foundation for further exploration of employee motivation and how to use HRM practices in the new era.