2014
DOI: 10.3389/fncel.2014.00096
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Hox gene regulation in the central nervous system of Drosophila

Abstract: Hox genes specify the structures that form along the anteroposterior (AP) axis of bilateria. Within the genome, they often form clusters where, remarkably enough, their position within the clusters reflects the relative positions of the structures they specify along the AP axis. This correspondence between genomic organization and gene expression pattern has been conserved through evolution and provides a unique opportunity to study how chromosomal context affects gene regulation. In Drosophila, a general rule… Show more

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Cited by 32 publications
(25 citation statements)
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“…While the role of Hox genes in determining the identity of body segments is well established, our findings bring into light the collective role of Hox genes in determining the size, shape and identity of body segments. Our observations are in agreement with a recent study which shows that in embryonic CNS of Drosophila the expression of abd-A is not suppressed by Abd-B and that the two genes coexpress in same nuclei [40] . These observations suggest that posterior dominance rule operating between abd-A and Abd-B is tissues specific and not a universal phenomenon.…”
Section: Discussionsupporting
confidence: 94%
“…While the role of Hox genes in determining the identity of body segments is well established, our findings bring into light the collective role of Hox genes in determining the size, shape and identity of body segments. Our observations are in agreement with a recent study which shows that in embryonic CNS of Drosophila the expression of abd-A is not suppressed by Abd-B and that the two genes coexpress in same nuclei [40] . These observations suggest that posterior dominance rule operating between abd-A and Abd-B is tissues specific and not a universal phenomenon.…”
Section: Discussionsupporting
confidence: 94%
“…Current knowledge regarding lncRNA's role in synaptogenesis and plasticity is relatively scarce. Studies found lncRNAs seem to regulate circadian or mating behavior in insects and worms (Soshnev et al, 2011 ; Gummalla et al, 2014 ), such evidence hasn't been found in mammals yet. Future genome-wide lncRNA knockout studies in mice would unveil the extent and mechanisms how lncRNAs are involved in circuitry dynamics.…”
Section: Lncrnas' Roles In Neurite Outgrowth Synaptogenesis and Synmentioning
confidence: 99%
“…Hsr-omega nullisomic mutants resulted in embryonic lethality [ [86] , [87] , [88] ]. Recent studies also demonstrated the regulation of lncRNAs in neurogenesis and their molecular mechanism in flies [ 89 , 90 ]. Neurogenic lncRNAs are expressed specifically during early stages of nervous system development and mark specific subsets of neurogenic cell types including neurons and glia [ 89 ].…”
Section: The Physiological Functions Of Lncrna In Animalsmentioning
confidence: 99%