HOXB4 promotes the malignant progression of ovarian cancer via DHDDS

Li, Na; Xiong, Jianping; Li, Zhengyu

doi:10.21203/rs.2.18907/v2

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…HOXB4, a member of the Antp homeobox protein family, regulates embryonic development and participates in tumor progression as an oncogene or tumor suppressor gene. In ovarian cancer, the expression of HOXB4 was closely related to poor prognosis and transcriptionally activated DHDDS to stimulate the proliferation and invasion of tumor cells 23 . Other studies also revealed that HOXB4 was upregulated in ovarian cancer cells and drug-resistant cells 35 .…”

Section: Discussionmentioning

confidence: 99%

“…HOXB4, the positive regulator implicated in the self-renewal of hematopoietic stem cells (HSCs) 21 , has been recognized as an oncogene or a tumor suppressor gene, depending on the specific type of cancer. HOXB4 was overexpressed in many cancers, including ovarian cancer 22,23 , cervical cancer [24][25][26][27] , lung cancer 28 , renal cancer 29 , mesothelioma 30 , and leukemia [31][32][33][34] , which promoted tumor growth and metastasis 23 . Moreover, increased HOXB4 expression resulted in drug resistance 31,35 .…”

Section: Introductionmentioning

confidence: 99%

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HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

2021

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Homeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and tumorigenesis. However, its biological function and exact mechanism in cervical cancer remain unknown. Here, we found that HOXB4 was markedly downregulated in cervical cancer. We demonstrated that HOXB4 obviously suppressed cervical cancer cell proliferation and tumorigenic potential in nude mice. Additionally, HOXB4-induced cell cycle arrest at the transition from the G0/G1 phase to the S phase. Conversely, loss of HOXB4 promoted cervical cancer cell growth both in vitro and in vivo. Bioinformatics analyses and mechanistic studies revealed that HOXB4 inhibited the activity of the Wnt/β-catenin signaling pathway by direct transcriptional repression of β-catenin. Furthermore, β-catenin re-expression rescued HOXB4-induced cervical cancer cell defects. Taken together, these findings suggested that HOXB4 directly transcriptional repressed β-catenin and subsequently inactivated the Wnt/β-catenin signaling pathway, leading to significant inhibition of cervical cancer cell growth and tumor formation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

2021

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“…PPP1CC plays an important role in regulating the GPCR signaling pathways 34 . HOXB4 can induce the expansion of hematopoietic and promote the malignant progression of ovarian cancer 35, 36 . Arg1 is related to the tumor-associated macrophage and inflammation resolution 37 .…”

Section: Discussionmentioning

confidence: 99%

Identification of biomarkers and pathways of mouse embryonic fibroblasts with the dysfunction of mitochondrial DNA

2021

Preprint

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Mitochondrial diseases are clinically heterogeneous which involve multiple systems such as organs that are highly dependent on metabolism. Dysfunction of mtDNA is the main cause of mitochondrial diseases that trigger inflammation and immune responses. Here, we aim to identify the biological function and pathways of MEFs with the dysfunction of mtDNA through deletion of YME1L. The gene expression profiles of GSE161735 dataset were originally created by the Illumina NovaSeq 6000 (Mus musculus) for gene biogenesis and function panel. The biological and functional pathways were analyzed by the Kyoto Encyclopedia of Genes and Genomes pathway (KEGG), Gene Ontology (GO), and Reactom visual map. KEGG and GO results showed the metabolism and immune responses were mostly affected by the loss of mtDNA. Moreover, we discovered several interacting genes including POLR2F, HIST1H2BJ, PPP1CC, HOXB4, ARG1, APITD1, BUB1B, POLR2K, HOXC4, and HOXB3 were involved in the regulation of metabolic or cancer diseases. Further, we predicted several regulators that had the ability to affect mitochondria during the dysfunction of mtDNA by L1000fwd analysis. Thus, this study provides further insights into the mechanism of mtDNA in metabolic diseases.

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HOXB4 promotes the malignant progression of ovarian cancer via DHDDS

Abstract: Background : Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types.

Cited by 2 publications

References 36 publications

HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

Identification of biomarkers and pathways of mouse embryonic fibroblasts with the dysfunction of mitochondrial DNA

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