HP-09-006 First Results of Platelet-rich Plasma and Low Intensity Extracorporeal Shockwave Combined Therapy for Erectile Dysfunction

Epifanova, M.; Gvasalia, B.; Artemenko, S.; Durashov, M.

doi:10.1016/j.jsxm.2019.03.164

Cited by 2 publications

(2 citation statements)

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“…Other studies have been done evaluating the combination therapy of Li-SWT and PRP (as well as other combination treatments), however some of these studies lack control groups and thus cannot be used to evaluate the effects of PRP alone in ED ( 43 , 44 , 49 , 50 ). It should be noted that Li-SWT has not been proven unequivocally to be of benefit in ED, with data from prospective randomized trials showing conflicting results ( 7 ).…”

Section: Review Of the Current Evidencementioning

confidence: 99%

Erectile dysfunction: Is platelet-rich plasma the new frontier for treatment in patients with erectile dysfunction? A review of the existing evidence

Anastasiadis

Ahmed

Khoja

et al. 2022

Front. Reprod. Health

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Erectile dysfunction (ED) is one of the commonest disorders in adult males and affects 12–19% of men of reproductive age. Only few studies have evaluated the impact of ED on men and couples with infertility—these studies report higher rates of ED in this sub-group of men compared to the general population, with the prevalence of ED in men diagnosed with male infertility ranging from 6.7 to 61.6%. Nevertheless, ED is considered a rare cause of male infertility, accounting for about 0.4–5% of all causes of male infertility. ED remains a poorly treated condition globally and current therapies, like oral medication, offer only temporary symptomatic relief and do not influence disease progression—patients are potentially on lifelong treatment, with ED worsening over time. In contrast, regenerative medicine may potentially reverse or halt the progression of ED processes. In this article, we review the evidence for intracavernosal injections of platelet-rich plasma (PRP) in the treatment of ED.

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Section: Review Of the Current Evidencementioning

confidence: 99%

Erectile dysfunction: Is platelet-rich plasma the new frontier for treatment in patients with erectile dysfunction? A review of the existing evidence

Anastasiadis

Ahmed

Khoja

et al. 2022

Front. Reprod. Health

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“…Therefore, PRP may be applied as a filler or scaffolds to bridge nerve conduits, as PRP rich in fibrin matrix controls the sustained release of neurotrophic growth factors, which regulate angiogenesis, inflammation, apoptosis, fibrosis, and muscle atrophy, thereby promoting rapid regeneration of the injured peripheral nerve gap [128]. This therapeutic functional recovery is also associated with PRP's potential to maintain balance between the synthesis of collagen I, III, and IV [129]. To prevent the concern of early wash out, PRP could be converted to platelet-rich fibrin (PRF) rich in fibrinogen, fibronectin, platelets, leukocytes, and other growth factors [124].…”

Section: Clinical Efficacy Of Prp In Edmentioning

confidence: 99%

Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction

Liu

Chang

Wang³

et al. 2020

Cells

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Erectile dysfunction (ED) is an inability to attain or maintain adequate penile erection for successful vaginal intercourse, leading to sexual and relationship dissatisfaction. To combat ED, various surgical and non-surgical approaches have been developed in the past to restore erectile functions. These therapeutic interventions exhibit significant impact in providing relief to patients; however, due to their associated adverse effects and lack of long-term efficacy, newer modalities such as regenerative therapeutics have gained attention due to their safe and prolonged efficacy. Stem cells and platelet-derived biomaterials contained in platelet-rich plasma (PRP) are thriving as some of the major therapeutic regenerative agents. In recent years, various preclinical and clinical studies have evaluated the individual, as well as combined of stem cells and PRP to restore erectile function. Being rich in growth factors, chemokines, and angiogenic factors, both stem cells and PRP play a crucial role in regenerating nerve cells, myelination of axons, homing and migration of progenitor cells, and anti-fibrosis and anti-apoptosis of damaged cavernous nerve in corporal tissues. Further, platelet-derived biomaterials have been proven to be a biological supplement for enhancing the proliferative and differentiation potential of stem cells towards neurogenic fate. Therefore, this article comprehensively analyzes the progresses of these regenerative therapies for ED.

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HP-09-006 First Results of Platelet-rich Plasma and Low Intensity Extracorporeal Shockwave Combined Therapy for Erectile Dysfunction

Cited by 2 publications

References 0 publications

Erectile dysfunction: Is platelet-rich plasma the new frontier for treatment in patients with erectile dysfunction? A review of the existing evidence

Erectile dysfunction: Is platelet-rich plasma the new frontier for treatment in patients with erectile dysfunction? A review of the existing evidence

Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction

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