2005
DOI: 10.1016/j.legalmed.2004.10.002
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HPLC analysis of anti-malaria agent, chloroquine in blood and tissue from forensic autopsy cases in Tanzania

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Cited by 13 publications
(12 citation statements)
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“…Quantification of drugs in biological matrices by liquid chromatography/tandem mass spectrometry (LC-MS/MS) is becoming more common, owing to the improved sensitivity and selectivity of this technique [32]. LC-MS/MS requires less extensive sample preparation, hence chloroquine can be detected directly without solid phase extraction [4,12] or liquid-liquid extraction [5,6,11,13,14] techniques, which are expensive, time consuming and tedious. Recently, Samanidou et al [4] has reported an HPLC method for the quantification of quinine and chloroquine in plasma using solid phase extraction (SPE) with satisfactory sensitivity but it required long analysis time.…”
Section: Introductionmentioning
confidence: 99%
“…Quantification of drugs in biological matrices by liquid chromatography/tandem mass spectrometry (LC-MS/MS) is becoming more common, owing to the improved sensitivity and selectivity of this technique [32]. LC-MS/MS requires less extensive sample preparation, hence chloroquine can be detected directly without solid phase extraction [4,12] or liquid-liquid extraction [5,6,11,13,14] techniques, which are expensive, time consuming and tedious. Recently, Samanidou et al [4] has reported an HPLC method for the quantification of quinine and chloroquine in plasma using solid phase extraction (SPE) with satisfactory sensitivity but it required long analysis time.…”
Section: Introductionmentioning
confidence: 99%
“…(2). PND (2) thus obtained was mixed with distilled water (10 eq, 16.7 mL) and ortho phosphoric acid (7.5 eq, 3.59 g) and stirred at room temperature for 30 min.…”
Section: Resultsmentioning
confidence: 99%
“…Chloroquine, a 4-aminoquinoline derivative, emerged during the first part of the 20 th century as the drug of choice against malaria. 2,3 It proved to be the most successful antimalarial drug on a worldwide scale owing to its wide deployment coinciding with the geographical distribution of Plasmodium and also for its high intrinsic antiparasitic efficacy and low toxicity. 4 However, the malarial parasite P. falciparum has started to develop a widespread resistance to chloroquine and this has become a major cause for concern.…”
Section: Introductionmentioning
confidence: 99%
“…Generally, a traditional RP18 column was hard to reserve solar or basic compounds such as chloroquine. Most of the aforementioned methods used gradient elution [9,13] or relatively high proportion of aqueous phase [8,[10][11][12] to retain the analytes. Still, these methods have obvious drawbacks, including a requirement of large injection volumes (up to 100 μl), long analysis times (especially combined with gradient elution), low sensitivity and limited selectivity, and therefore make it not suitable for fast and robust detection.…”
Section: Our Assaymentioning
confidence: 99%
“…Although many analytical methods have been developed for the detection of chloroquine, most of these use expensive solid phase extraction (SPE) columns [7][8][9] or require time-consuming liquid-liquid extractions (LLE) combined with extra preacidification operation [10][11][12] and/or prealkalization [10][11][12][13] procedure and then processed to an ultraviolet detector [7][8][9][10][11][12][13]. Brief summary of existing HPLC methods for the analysis Development and validation of an HILIC-MS/MS method by one-step precipitation for chloroquine in miniature pig plasma future science group Methodology Wang, Lu, Shang, Ni, Zhang & Wen Table 1.…”
Section: Introductionmentioning
confidence: 99%