HPLC analysis of steroid esters

Matlin, Stephen A.; Chan, Lam; Prazeres, M. A.

doi:10.1002/jhrc.1240071010

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…The diastereomer composition of the esters of some steroids (norethisterone and levonorgestrel) was studied using a column (10-25cmx4.5mm) filled with Hypersil and ODS-Hypersil and eluted with MeCN-CH2C12 (5 : 95) and MeOH-H20 (90:10, 80:20) mixtures; the samples were detected at 243 nm [78].…”

Section: Liquid Chromatography and Hplcmentioning

confidence: 99%

Methods of control and standardization of drugs containing progestogen hormones (A review)

et al. 1998

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The group of progestogen hormones includes progesterone (corpus luteum hormone) and a number of synthetic preparations with a structure close to that of progesterone (norethisterone, lynestrenol, levonorgestrel, desogestrel, etc.).The process of state control of the commercial progestogen hormonal preparations and the corresponding normative documentation are not free of significant drawbacks (in particular, some documents operative in the Russian Federation do not regulate the contents of related steroids). For this reason, the problems pertaining to the increase in the level of standardization and control of the quality of progestogen hormonal preparations require permanent attention and thorough consideration.A lot of information concerning the analysis of progestogen hormones is contained in the monograph of G6rrg [1]. However, there are some new data accumulated since that publication.The main methods used for the analysis of progesterone and related drugs were reviewed in [2].An analysis of the published data shows that the authenticity of ethisterone [3][4][5], norethisterone [4,5], and hydroxyprogesterone capronate [5] is established using a color reaction with sulfuric acid; levonorgestrel is identified by its reaction with m-dinitrobenzene in alkaline medium [5]; ethis-I State Research Institute of Drug Standardization and Control, Ministry of Health and Medical Industry, Moscow, Russia.

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Section: Liquid Chromatography and Hplcmentioning

confidence: 99%

Methods of control and standardization of drugs containing progestogen hormones (A review)

et al. 1998

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“…exists only in the aldehyde form in the crystalline state. The gossypol sample used for our studies was racemic; however, owing to the restricted rotation around the C(2)--C(12) bond, optically active gossypol can also be isolated (King & de Silva, 1968;Matlin, Belenguer, Tyson & Brookes, 1987). The steric hindrance between the substituents ortho to the C(2)--C(12) bond give rise to the nearly perpendicular orientation of the naphthyl moieties.…”

Section: Ho/y ~ Oh "~0mentioning

confidence: 99%

Lattice inclusion complexes of gossypol. Structure of the 1:1 complex of gossypol with acetonitrile

Gdaniec¹,

Ибрагимов²,

Dadabaev³

1990

Acta Crystallogr C

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Preparative HPLC. Part 1: A comparison of three types of equipment for the purification of steroids

Matlin

Chan

1984

J. High Resol. Chromatogr.

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Two commercial preparative liquid chroniatographs have been evaluated for gram-scale purification of steroid esters. The Jobin-Yvon and Waters chromatographs both allow fast separations. Neither system has a high intrinsic column efficiency, but the resolving power of the Waters system can be increased by the use of recycle. A laboratory-assembled preparative liquid chromatograph is described which is ecconomical both in construction and operation, versatile, and considerably more efficient than the two commercial alternatives for single runs on up to a gram scale.

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HPLC analysis of steroid esters

Cited by 6 publications

References 3 publications

Methods of control and standardization of drugs containing progestogen hormones (A review)

Methods of control and standardization of drugs containing progestogen hormones (A review)

Lattice inclusion complexes of gossypol. Structure of the 1:1 complex of gossypol with acetonitrile

Preparative HPLC. Part 1: A comparison of three types of equipment for the purification of steroids

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