HPLC Analysis of the Urinary Iodine Concentration in Pregnant Women

Mikulska, Aniceta Ada; Filipowicz, Dorota; Główka, Franciszek; Szczepanek‐Parulska, Ewelina; Ruchała, Marek; Bartecki, Michał; Karaźniewicz−Łada, Marta

doi:10.3390/molecules26226797

Cited by 6 publications

(22 citation statements)

References 43 publications

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“…The World Health Organization (WHOs) also recommends that urine assessments be used to measure iodine levels in people ( 27 ). And Several studies have shown that urine iodine can be used as a proxy measure of dietary iodine content ( 28 , 29 ). To sum up, urinary iodine concentration (UIC) was used indirectly as an indicator to estimate iodine consumption in the study, as there was a good correlation between iodine content in urine and intake.…”

Section: Methodsmentioning

confidence: 99%

Associations between urinary iodine concentration and the prevalence of metabolic disorders: a cross-sectional study

et al. 2023

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BackgroundFew studies have examined the role of iodine in extrathyroidal function. Recent research has shown an association between iodine and metabolic syndromes (MetS) in Chinese and Korean populations, but the link in the American participants remains unknown.PurposeThis study aimed to examine the relationship between iodine status and metabolic disorders, including components associated with metabolic syndrome, hypertension, hyperglycemia, central obesity, triglyceride abnormalities, and low HDL.MethodsThe study included 11,545 adults aged ≥ 18 years from the US National Health and Nutrition Examination Survey (2007–2018). Participants were divided into four groups based on their iodine nutritional status(ug/L), as recommended by the World Health Organization: low UIC, < 100; normal UIC, 100-299; high UIC, 300-399; and very high, ≥ 400. The Odds ratio (OR) for MetS basing the UIC group was estimated using logistic regression models for our overall population and subgroups.ResultsIodine status was positively associated with the prevalence of MetS in US adults. The risk of MetS was significantly higher in those with high UIC than in those with normal UIC [OR: 1.25; 95% confidence intervals (CI),1.016-1.539; p = 0.035). The risk of MetS was lower in the low UIC group (OR,0.82; 95% CI: 0.708-0.946; p = 0.007). There was a significant nonlinear trend between UIC and the risk of MetS, diabetes, and obesity in overall participants. Participants with high UIC had significantly increased TG elevation (OR, 1.24; 95% CI: 1.002-1.533; P = 0.048) and participants with very high UIC had significantly decreased risk of diabetes (OR, 0.83; 95% CI: 0.731-0.945, p = 0.005). Moreover, subgroup analysis revealed an interaction between UIC and MetS in participants aged < 60 years and ≥ 60 years, and no association between UIC and MetS in older participants aged ≥ 60 years.ConclusionOur study validated the relationship between UIC and MetS and their components in US adults. This association may provide further dietary control strategies for the management of patients with metabolic disorders.

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Section: Methodsmentioning

confidence: 99%

Associations between urinary iodine concentration and the prevalence of metabolic disorders: a cross-sectional study

et al. 2023

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“…Additionally, urine iodine concentration (UIC) is the most widely used indicator of iodine status [18][19][20], and the intake and excretion of iodine in human body are basically the same. A single urine iodine value cannot reflect an individual's iodine nutritional status, and urinary iodine determination results are influenced by season, diet, and other factors.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Urinary Iodine Concentration and the Prevalence of Thyroid Nodules and Subclinical Hypothyroidism

Zhu,

Chen,

Ding

et al. 2024

Horm Metab Res

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The aim of the study was to investigate the iodine intake in the resident population in Xi’an and analyze the relationship between iodine nutritional status and the prevalence of subclinical hypothyroidism and thyroid nodules (TNs). A total of 2507 people were enrolled in Xi’an. Venous serum thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), urinary iodine concentration (UIC), and thyroid ultrasonography were collected. Patients with abnormal TSH were checked for free thyroxine (FT4) and triiodothyronine (FT3). Adults in Xi’an had median UICs of 220.80 μg/L and 178.56 μg/l, respectively. A sum of 16.78% of people had subclinical hypothyroidism. Both iodine excess and iodine deficit increased the frequency of subclinical hypothyroidism. The lowest was around 15.09% in females with urine iodine levels between 200 and 299 μg/l. With a rate of 10.69%, the lowest prevalence range for males was 100–199 μg/l. In Xi’an, 11.37% of people have TNs. In comparison to other UIC categories, TN occurrences were higher in females (18.5%) and males (12%) when UIC were below 100 μg/l. In conclusion, iodine intake was sufficient in the Xi’an area, while the adults’ UIC remains slightly higher than the criteria. Iodine excess or deficiency can lead to an increase in the prevalence of subclinical hypothyroidism. Patients with iodine deficiency are more likely to develop TNs.

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“…It is well known that almost all iodine ingested by the body is excreted in the urine (Vejbjerg et al, 2009), so most of the iodine is present in the body in the form of urinary iodine. Several studies have shown that urinary iodine can be used as a surrogate measure of dietary iodine content (Andersen et al, 2015; Mikulska et al, 2021). Similarly, the World Health Organization (WHO) recommends the use of urine assessments to measure people's iodine levels (Peniamina et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dietary protein intake affects the association between urinary iodine and clinically relevant depression: Evidence from NHANES 2007–2018

Kong

Shen

Yang

et al. 2023

Food Science & Nutrition

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Both iodine concentration and protein intake are important nutritional factors that may influence the development of depressive symptoms. However, there are no studies on the effect of protein intake on the relationship between iodine concentration and the risk of depression. The study aimed to explore the relationship between iodine and the risk of clinically relevant depression (CRD) according to protein intake. This study analyzed the adults (≥18 years) who participated in the 2007–2018 National Health and Nutrition Cross‐sectional Survey (N = 10,462). CRD was assessed using the Patient Health Questionnaire (PHQ‐9). Protein intake was assessed using two 24‐h dietary recalls and urinary iodine concentration (UIC) was measured using inductively coupled plasma dynamic response cell mass spectrometry. Weighted multivariate logistic regression and restrictive cubic splines were performed to assess the relationship between UIC and CRD according to protein category (low protein intake <0.8 g/kg/day; high protein intake: ≥0.8 g/kg/day). After controlling for sociodemographic, behavioral, chronic diseases, and dietary factors, a positive correlation was observed between UIC (log10) and CRD (OR: 1.36, 95% CI: 1.026, 1.795). Low UIC (<100 μg/L) was associated with a lower prevalence of CRD (OR: 0.73, 95% CI: 0.533, 0.995) in high protein intake individuals, whereas this relationship did not exist in those with low protein intake. Moreover, restrictive cubic splines confirmed a near L‐shaped relationship between UIC and CRD in the low‐protein group (nonlinear p = .042) and a linear relationship between them in the high‐protein group (nonlinear p = .392). This study illustrates that protein intake affects the relationship between UIC and CRD. Combining lower UIC and high protein intake may help reduce the prevalence of CRD, which would have significant implications for managing patients with depressive CRD in the clinical setting.

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HPLC Analysis of the Urinary Iodine Concentration in Pregnant Women

Cited by 6 publications

References 43 publications

Associations between urinary iodine concentration and the prevalence of metabolic disorders: a cross-sectional study

Associations between urinary iodine concentration and the prevalence of metabolic disorders: a cross-sectional study

Relationship Between Urinary Iodine Concentration and the Prevalence of Thyroid Nodules and Subclinical Hypothyroidism

Dietary protein intake affects the association between urinary iodine and clinically relevant depression: Evidence from NHANES 2007–2018

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